Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release

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http://hdl.handle.net/10138/224680

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Herranz- Blanco , B , Arriaga , L R , Mäkilä , E , Correia , A , Shrestha , N , Mirza , S , Weitz , D A , Salonen , J , Hirvonen , J & Santos , H A 2014 , ' Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release ' , Lab on a Chip , vol. 14 , no. 6 , pp. 1083-1086 . https://doi.org/10.1039/c3lc51260f

Title: Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release
Author: Herranz- Blanco, Bárbara; Arriaga, Laura R.; Mäkilä, Ermei; Correia, Alexandra; Shrestha, Neha; Mirza, Sabiruddin; Weitz, David A.; Salonen, Jarno; Hirvonen, Jouni; Santos, Helder A.
Other contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy


Date: 2014
Language: eng
Number of pages: 4
Belongs to series: Lab on a Chip
ISSN: 1473-0197
DOI: https://doi.org/10.1039/c3lc51260f
URI: http://hdl.handle.net/10138/224680
Abstract: A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi–lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.
Subject: MESOPOROUS SILICON
IN-VITRO
SURFACE-CHEMISTRY
NANOPARTICLES
DELIVERY
MICROPARTICLES
MICROCAPSULES
POLYMERSOMES
LIPOSOMES
BIOCOMPATIBILITY
317 Pharmacy
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