Addressing the inter-individual variation in response to consumption of plant food bioactives : Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction

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Manach , C , Milenkovic , D , Van de Wiele , T , Rodriguez-Mateos , A , de Roos , B , Teresa Garcia-Conesa , M , Landberg , R , Gibney , E R , Heinonen , M , Tomas-Barberan , F & Morand , C 2017 , ' Addressing the inter-individual variation in response to consumption of plant food bioactives : Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction ' , Molecular Nutrition & Food Research , vol. 61 , no. 6 , 1600557 . https://doi.org/10.1002/mnfr.201600557

Title: Addressing the inter-individual variation in response to consumption of plant food bioactives : Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction
Author: Manach, Claudine; Milenkovic, Dragan; Van de Wiele, Tom; Rodriguez-Mateos, Ana; de Roos, Baukje; Teresa Garcia-Conesa, Maria; Landberg, Rikard; Gibney, Eileen R.; Heinonen, Marina; Tomas-Barberan, Francisco; Morand, Christine
Contributor: University of Helsinki, University of Helsinki
Date: 2017-06
Language: eng
Number of pages: 16
Belongs to series: Molecular Nutrition & Food Research
ISSN: 1613-4125
URI: http://hdl.handle.net/10138/225802
Abstract: Bioactive compounds in plant-based foods have health properties that contribute to the prevention of age-related chronic diseases, particularly cardiometabolic disorders. Conclusive proof and understanding of these benefits in humans is essential in order to provide effective dietary recommendations but, so far, the evidence obtained from human intervention trials is limited and contradictory. This is partly due to differences between individuals in the absorption, distribution, metabolism and excretion of bioactive compounds, as well as to heterogeneity in their biological response regarding cardiometabolic health outcomes. Identifying the main factors underlying inter-individual differences, as well as developing new and innovative methodologies to account for such variability constitute an overarching goal to ultimately optimize the beneficial health effects of plant food bioactives for each and every one of us. In this respect, this position paper from the COST Action FA1403-POSITIVe examines the main factors likely to affect the individual responses to consumption of plant food bioactives and presents perspectives for assessment and consideration of inter-individual variability.
Subject: Bioavailability and metabolism
Biological responsiveness
Cardiometabolic health
Inter-individual variation
Plant food bioactives
RANDOMIZED CONTROLLED-TRIAL
CORONARY-ARTERY-DISEASE
BLOOD MONONUCLEAR-CELLS
CARDIOVASCULAR-DISEASE
VEGETABLE CONSUMPTION
HEART-DISEASE
POSTMENOPAUSAL WOMEN
INTERVENTION TRIAL
PRODUCER PHENOTYPE
GENETIC-VARIANTS
416 Food Science
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