Assessment of blinding may be inappropriate after the trial : [Letter]

Show full item record



Permalink

http://hdl.handle.net/10138/228099

Citation

Hemilä , H 2005 , ' Assessment of blinding may be inappropriate after the trial : [Letter] ' , Contemporary Clinical Trials , vol. 26 , no. 4 , pp. 512-514 . https://doi.org/10.1016/j.cct.2005.04.002

Title: Assessment of blinding may be inappropriate after the trial : [Letter]
Author: Hemilä, Harri
Other contributor: University of Helsinki, Department of Public Health
Date: 2005
Language: eng
Number of pages: 3
Belongs to series: Contemporary Clinical Trials
ISSN: 1551-7144
DOI: https://doi.org/10.1016/j.cct.2005.04.002
URI: http://hdl.handle.net/10138/228099
Abstract: In their paper discussing the assessment of blinding in clinical trials, Bang et al. based their analysis on the premise that "all participants randomly guess their assignment... This is the most ideal scenario in reality". However, this premise makes an implicit assumption that the drug does not differ from placebo in any physiological effects that a person could observe subjectively, which is a very strong assumption. If a drug is truly effective, such as penicillin for pneumococcal pneumonia, both the patient and the physician can infer the treatment with high certainty by subjective observations. Thus, when the drug is truly effective, we are expecting "breaking of blindness".
Subject: VITAMIN-C
COMMON COLD
ASCORBIC-ACID
DISSENT
314 Health sciences
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
HH_2005_CCT_manu.pdf 13.78Kb PDF View/Open
1_s2.0_S1551714405000728_main.pdf 49.93Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record