Vitamin D and cognitive function : A Mendelian randomisation study

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Maddock , J , Zhou , A , Cavadino , A , Kuzma , E , Bao , Y , Smart , M C , Saum , K-U , Schoettker , B , Engmann , J , Kjaergaard , M , Karhunen , V , Zhan , Y , Lehtimaki , T , Rovio , S P , Byberg , L , Lahti , J , Marques-Vidal , P , Sen , A , Perna , L , Schirmer , H , Singh-Manoux , A , Auvinen , J , Hutri-Kahonen , N , Kahonen , M , Kilander , L , Raikkonen , K , Melhus , H , Ingelsson , E , Guessous , I , Petrovic , K E , Schmidt , H , Schmidt , R , Vollenweider , P , Lind , L , Eriksson , J G , Michaelsson , K , Raitakari , O T , Hagg , S , Pedersen , N L , Herzig , K-H , Jarvelin , M-R , Veijola , J , Kivimaki , M , Jorde , R , Brenner , H , Kumari , M , Power , C , Llewellyn , D J & Hypponen , E 2017 , ' Vitamin D and cognitive function : A Mendelian randomisation study ' , Scientific Reports , vol. 7 , 13230 . https://doi.org/10.1038/s41598-017-13189-3

Title: Vitamin D and cognitive function : A Mendelian randomisation study
Author: Maddock, Jane; Zhou, Ang; Cavadino, Alana; Kuzma, Elzbieta; Bao, Yanchun; Smart, Melissa C.; Saum, Kai-Uwe; Schoettker, Ben; Engmann, Jorgen; Kjaergaard, Marie; Karhunen, Ville; Zhan, Yiqiang; Lehtimaki, Terho; Rovio, Suvi P.; Byberg, Liisa; Lahti, Jari; Marques-Vidal, Pedro; Sen, Abhijit; Perna, Laura; Schirmer, Henrik; Singh-Manoux, Archana; Auvinen, Juha; Hutri-Kahonen, Nina; Kahonen, Mika; Kilander, Lena; Raikkonen, Katri; Melhus, Hakan; Ingelsson, Erik; Guessous, Idris; Petrovic, Katja E.; Schmidt, Helena; Schmidt, Reinhold; Vollenweider, Peter; Lind, Lars; Eriksson, Johan G.; Michaelsson, Karl; Raitakari, Olli T.; Hagg, Sara; Pedersen, Nancy L.; Herzig, Karl-Heinz; Jarvelin, Marjo-Riitta; Veijola, Juha; Kivimaki, Mika; Jorde, Rolf; Brenner, Hermann; Kumari, Meena; Power, Chris; Llewellyn, David J.; Hypponen, Elina
Contributor: University of Helsinki, Helsinki Collegium for Advanced Studies
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017-10-16
Language: eng
Number of pages: 8
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/228335
Abstract: The causal nature of the association between hypovitaminosis D and poor cognitive function in mid-to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memoryrelated cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p(curvature)
Subject: D DEFICIENCY
D SUPPLEMENTATION
METAANALYSIS
DEMENTIA
MICE
RECOMMENDATIONS
DETERMINANTS
ASSOCIATION
PERFORMANCE
IMPAIRMENT
3121 General medicine, internal medicine and other clinical medicine
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