Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection

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Fevola , C , Forbes , K M , Makela , S , Putkuri , N , Hauffe , H C , Kallio-Kokko , H , Mustonen , J , Jaaskelainen , A J & Vaheri , A 2016 , ' Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection ' , Journal of Clinical Virology , vol. 84 , pp. 48-52 . https://doi.org/10.1016/j.jcv.2016.10.002

Title: Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection
Author: Fevola, Cristina; Forbes, Kristian M.; Makela, Satu; Putkuri, Niina; Hauffe, Heidi C.; Kallio-Kokko, Hannimari; Mustonen, Jukka; Jaaskelainen, Anne J.; Vaheri, Antti
Contributor organization: Department of Virology
Medicum
Olli Pekka Vapalahti / Principal Investigator
Clinicum
Viral Zoonosis Research Unit
Date: 2016-11
Language: eng
Number of pages: 5
Belongs to series: Journal of Clinical Virology
ISSN: 1386-6532
DOI: https://doi.org/10.1016/j.jcv.2016.10.002
URI: http://hdl.handle.net/10138/229656
Abstract: Background: The emergence and re-emergence of zoonotic and vector-borne diseases are increasing in Europe. Prominent rodent-borne zoonotic viruses include Puumala hantavirus (PUUV; the causative agent of nephropathia epidemica, NE), lymphocytic choriomeningitis virus (LCMV), and orthopoxviruses (OPV). In addition, Ljungan virus (LV) is considered a potentially zoonotic virus. Objective: The aim of this study was to compare clinical picture between acute PUUV patients with and without additional rodent-borne viral infections, to investigate if concurrent infections influence disease severity. Study design: We evaluated seroprevalence of and seroconversions to LCMV, LV and OPV in 116 patients hospitalized for NE. Clinical and laboratory variables were closely monitored during hospital care. Results: A total of five LCMV, 15 LV, and one OPV seroconversions occurred. NE patients with LCMV seroconversions were younger, and had lower plasma creatinine concentrations and platelet counts than patients without LCMV seroconversions. No differences occurred in clinical or laboratory findings between patients with and without seroconversions to LV and OPV. We report, for the first time, LCMV seroprevalence in Finland, with 8.5% of NE patients seropositive for this virus. Seroprevalences for LV and OPV were 47.8% and 32.4%, respectively. Conclusion: Cases with LCMV seroconversions were statistically younger, had milder acute kidney injury and more severe thrombocytopenia than patients without LCMV. However, the low number of seroconversion cases precludes firm conclusions. Concurrent LV or OPV infections do not appear to influence clinical picture for NE patients. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Lymphocytic choriomeningitis virus
Ljungan virus
Orthopox virus
Puumala hantavirus
Seroprevalence
Zoonosis
SEROLOGICAL SURVEY
VIRUS-INFECTION
WILD RODENTS
VOLES
ANTIBODIES
POPULATION
PREVALENCE
COWPOX
SEROPREVALENCE
MYOCARDITIS
3111 Biomedicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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