AHR in energy balance regulation

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http://hdl.handle.net/10138/231148

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Pohjanvirta , R 2017 , ' AHR in energy balance regulation ' Current opinion in toxicology , vol. 2 , pp. 8-14 .

Title: AHR in energy balance regulation
Author: Pohjanvirta, Raimo
Contributor: University of Helsinki, Food Hygiene and Environmental Health
Date: 2017-02
Language: eng
Number of pages: 7
Belongs to series: Current opinion in toxicology
ISSN: 2468-2020
URI: http://hdl.handle.net/10138/231148
Abstract: Recent studies on mice genetically modified at the Ahr locus and fed on high-fat diet have revealed a novel physiological role for the AHR in energy balance. Globally impaired function of the receptor counteracts the development of obesity by increasing energy expenditure, which appears to occur mostly in the skeletal muscle and brown adipose tissue. On the other hand, global and tissue-specific loss of AHR signaling can have opposite effects on liver fat content and their impact on insulin sensitivity is also context-dependent. As tryptophan metabolites are key AHR activators, these findings suggest that the AHR may act as a protein sensor enabling adequate protein intake from low-protein diets by allowing calorie overfeeding without resultant obesity.
Subject: 3111 Biomedicine
AH RECEPTOR
Energy balance
Brown adipose tissue
White adipose tissue
Diet-induced obesity
HIGH-FAT DIET
Knockout mice
GLUCOSE TOLERANCE
INSULIN SENSITIVITY
TRYPTOPHAN
OBESITY
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