Coordinated responses of natural anticoagulants to allogeneic stem cell transplantation and acute GVHD - A longitudinal study

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http://hdl.handle.net/10138/231268

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Przybyla , B , Pinomäki , A , Petäjä , J , Joutsi-Korhonen , L , Strandberg , K , Hillarp , A , Öhlin , A-K , Ruutu , T , Volin , L & Lassila , R 2017 , ' Coordinated responses of natural anticoagulants to allogeneic stem cell transplantation and acute GVHD - A longitudinal study ' , PLoS One , vol. 12 , no. 12 , 0190007 . https://doi.org/10.1371/journal.pone.0190007

Title: Coordinated responses of natural anticoagulants to allogeneic stem cell transplantation and acute GVHD - A longitudinal study
Author: Przybyla, Beata; Pinomäki, Anne; Petäjä, Jari; Joutsi-Korhonen, Lotta; Strandberg, Karin; Hillarp, Andreas; Öhlin, Ann-Kristin; Ruutu, Tapani; Volin, Liisa; Lassila, Riitta
Contributor: University of Helsinki, HUS Comprehensive Cancer Center
University of Helsinki, Department of Oncology
University of Helsinki, Children's Hospital
University of Helsinki, Department of Clinical Chemistry and Hematology
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017-12-22
Language: eng
Number of pages: 11
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/231268
Abstract: Background Allogeneic stem cell transplantation (SCT) enhances coagulation via endothelial perturbation and inflammation. Role of natural anticoagulants in interactions between coagulation and inflammation as well as in acute graft-versus-host disease (GVHD) are not well known. The purpose of this study was to define changes in natural anticoagulants over time in association with GVHD. Patients and methods This prospective study included 30 patients who received grafts from siblings (n = 19) or unrelated donors (n = 11). Eight patients developed GVHD. Standard clinical assays were applied to measure natural anticoagulants, represented by protein C (PC), antithrombin (AT), protein S (PS), complex of activated PC with its inhibitor (APC-PCI) and by markers of endothelial activation: Factor VIII coagulant activity (FVIII: C) and soluble thrombomodulin (s-TM) at 6-8 time points over three months. Results Overall, PC, AT and FVIII: C increased in parallel after engraftment. Significant correlations between PC and FVIII: C (r = 0.64-0.82, p Conclusion The coordinated activation of natural anticoagulants in our longitudinal study indicates the sustained ability of adaptation to endothelial and inflammatory activation during allogenic SCT treatment. The suboptimal control of coagulation by natural anticoagulants at early stage of SCT may contribute to onset of GVHD.
Subject: BONE-MARROW-TRANSPLANTATION
ACTIVATED PROTEIN-C
VERSUS-HOST-DISEASE
THROMBOMODULIN
COMPLICATIONS
COAGULATION
DEFICIENCY
RECIPIENTS
COMPLEX
PLASMA
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
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