A Protein Diet Score, Including Plant and Animal Protein, Investigating the Association with HbA1c and eGFR-The PREVIEW Project

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Moller , G , Sluik , D , Ritz , C , Mikkilä , V , Raitakari , O T , Hutri-Kähönen , N , Dragsted , L O , Larsen , T M , Poppitt , S D , Silvestre , M P , Feskens , E J M , Brand-Miller , J & Raben , A 2017 , ' A Protein Diet Score, Including Plant and Animal Protein, Investigating the Association with HbA1c and eGFR-The PREVIEW Project ' , Nutrients , vol. 9 , no. 7 , 763 . https://doi.org/10.3390/nu9070763

Title: A Protein Diet Score, Including Plant and Animal Protein, Investigating the Association with HbA1c and eGFR-The PREVIEW Project
Author: Moller, Grith; Sluik, Diewertje; Ritz, Christian; Mikkilä, Vera; Raitakari, Olli T.; Hutri-Kähönen, Nina; Dragsted, Lars O.; Larsen, Thomas M.; Poppitt, Sally D.; Silvestre, Marta P.; Feskens, Edith J. M.; Brand-Miller, Jennie; Raben, Anne
Other contributor: University of Helsinki, Department of Food and Nutrition

Date: 2017-07
Language: eng
Number of pages: 14
Belongs to series: Nutrients
ISSN: 2072-6643
DOI: https://doi.org/10.3390/nu9070763
URI: http://hdl.handle.net/10138/232800
Abstract: Higher-protein diets have been advocated for body-weight regulation for the past few decades. However, the potential health risks of these diets are still uncertain. We aimed to develop a protein score based on the quantity and source of protein, and to examine the association of the score with glycated haemoglobin (HbA1c) and estimated glomerular filtration rate (eGFR). Analyses were based on three population studies included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World): NQplus, Lifelines, and the Young Finns Study. Cross-sectional data from food-frequency questionnaires (n = 76,777 subjects) were used to develop a protein score consisting of two components: 1) percentage of energy from total protein, and 2) plant to animal protein ratio. An inverse association between protein score and HbA1c (slope -0.02 +/- 0.01 mmol/mol, p <0.001) was seen in Lifelines. We found a positive association between the protein score and eGFR in Lifelines (slope 0.17 +/- 0.02 mL/min/1.73 m(2), p <0.0001). Protein scoring might be a useful tool to assess both the effect of quantity and source of protein on health parameters. Further studies are needed to validate this newly developed protein score.
Subject: protein diet score
HbA1c
eGFR
healthy subjects
population studies
GLOMERULAR-FILTRATION-RATE
MEAT CONSUMPTION
LOW-CARBOHYDRATE
KIDNEY-FUNCTION
RENAL-FUNCTION
HEART-DISEASE
RISK-FACTOR
ALL-CAUSE
WOMEN
ADULTS
416 Food Science
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