DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

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dc.contributor.author Borssén, Magnus
dc.contributor.author Nordlund, Jessica
dc.contributor.author Haider, Zahra
dc.contributor.author Landfors, Mattias
dc.contributor.author Larsson, Pär
dc.contributor.author Kanerva, Jukka
dc.contributor.author Schmiegelow, Kjeld
dc.contributor.author Flaegstad, Trond
dc.contributor.author Jónsson, Ólafur G
dc.contributor.author Frost, Britt-Marie
dc.contributor.author Palle, Josefine
dc.contributor.author Forestier, Erik
dc.contributor.author Heyman, Mats
dc.contributor.author Hultdin, Magnus
dc.contributor.author Lönnerholm, Gudmar
dc.contributor.author Degerman, Sofie
dc.date.accessioned 2018-03-11T04:22:45Z
dc.date.available 2018-03-11T04:22:45Z
dc.date.issued 2018-03-05
dc.identifier.citation Clinical Epigenetics. 2018 Mar 05;10(1):31
dc.identifier.uri http://hdl.handle.net/10138/233337
dc.description.abstract Abstract Background Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. Methods Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1–18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. Results Among the 137 patients that later relapsed, patients with a CIMP− profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. Conclusion CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.
dc.publisher BioMed Central
dc.subject DNA methylation
dc.subject BCP-ALL
dc.subject Prognosis
dc.subject CIMP
dc.subject Relapse
dc.subject Risk stratification
dc.title DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
dc.date.updated 2018-03-11T04:22:46Z
dc.language.rfc3066 en
dc.rights.holder The Author(s).
dc.type.uri http://purl.org/eprint/entityType/ScholarlyWork
dc.type.uri http://purl.org/eprint/entityType/Expression
dc.type.uri http://purl.org/eprint/type/JournalArticle

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