A minireview on the in vitro and in vivo experiments with anti-Escherichia coli O157 : H7 phages as potential biocontrol and phage therapy agents

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Sabouri , S , Sepehrizadeh , Z , Amirpour-Rostami , S & Skurnik , M 2017 , ' A minireview on the in vitro and in vivo experiments with anti-Escherichia coli O157 : H7 phages as potential biocontrol and phage therapy agents ' , International Journal of Food Microbiology , vol. 243 , pp. 52-57 . https://doi.org/10.1016/j.ijfoodmicro.2016.12.004

Title: A minireview on the in vitro and in vivo experiments with anti-Escherichia coli O157 : H7 phages as potential biocontrol and phage therapy agents
Author: Sabouri, Salehe; Sepehrizadeh, Zargham; Amirpour-Rostami, Sahar; Skurnik, Mikael
Contributor: University of Helsinki, Research Programs Unit
Date: 2017-02-21
Language: eng
Number of pages: 6
Belongs to series: International Journal of Food Microbiology
ISSN: 0168-1605
URI: http://hdl.handle.net/10138/233867
Abstract: Phage therapy is an old method of combating bacterial pathogens that has recently been taken into consideration due to the alarming spread of antibiotic resistance. Escherichia coli 0157:H7 is a foodborne pathogen that causes hemorrhagic colitis and life-threatening Hemolytic Uremic Syndrome (HUS). There are several studies on isolation of specific phages against E. coli 0157:H7 and more than 60 specific phase have been published so far. Although in vitro experiments have been successful in elimination or reduction of E. coli 0157:H7numbers, in vivo experiments have not been as promising. This may be due to escape of bacteria to locations where phages have difficulties to enter or due to the adverse conditions in the gastrointestinal tract that affect phage viability and proliferation. To get around the latter obstacle, an alternative phage delivery method such as polymer microen-capsulation should be tried. While the present time results are not very encouraging the work should be continued as more efficient phage treatment regimens might be found in future. (C)2016 Elsevier B.V. All rights reserved.
Subject: EHEC
Bacteriophages
Biocontrol
Antimicrobials
COMPLETE GENOME SEQUENCE
FEEDLOT CATTLE
BACTERIOPHAGE THERAPY
O157-H7 LEVELS
ORAL DELIVERY
COCKTAIL
O157/H7
BEEF
INACTIVATION
SALMONELLA
1183 Plant biology, microbiology, virology
3111 Biomedicine
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