DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

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http://hdl.handle.net/10138/233930

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Borssen , M , Nordlund , J , Haider , Z , Landfors , M , Larsson , P , Kanerva , J , Schmiegelow , K , Flaegstad , T , Jonsson , O G , Frost , B-M , Palle , J , Forestier , E , Heyman , M , Hultdin , M , Lonnerholm , G & Degerman , S 2018 , ' DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia ' , Clinical epigenetics , vol. 10 , 31 . https://doi.org/10.1186/s13148-018-0466-3

Title: DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
Author: Borssen, Magnus; Nordlund, Jessica; Haider, Zahra; Landfors, Mattias; Larsson, Par; Kanerva, Jukka; Schmiegelow, Kjeld; Flaegstad, Trond; Jonsson, Olafur Gisli; Frost, Britt-Marie; Palle, Josefine; Forestier, Erik; Heyman, Mats; Hultdin, Magnus; Lonnerholm, Gudmar; Degerman, Sofie
Other contributor: University of Helsinki, Children's Hospital



Date: 2018-03-05
Language: eng
Number of pages: 7
Belongs to series: Clinical epigenetics
ISSN: 1868-7083
DOI: https://doi.org/10.1186/s13148-018-0466-3
URI: http://hdl.handle.net/10138/233930
Abstract: Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. Results: Among the 137 patients that later relapsed, patients with a CIMP-profile (n = 42) at initial diagnosis had an inferior overall survival (pOS(5years) 33%) compared to CIMP+ patients (n = 95, pOS(5years) 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.
Subject: DNA methylation
BCP-ALL
Prognosis
CIMP
Relapse
Risk stratification
MINIMAL RESIDUAL DISEASE
LESSONS
3122 Cancers
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