The CODATwins Project : The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

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Silventoinen , K , Jelenkovic , A , Sund , R , Honda , C , Aaltonen , S , Yokoyama , Y , Tarnoki , A D , Tarnoki , D L , Ning , F , Ji , F , Pang , Z , Ordonana , J R , Sanchez-Romera , J F , Colodro-Conde , L , Burt , S A , Klump , K L , Medland , S E , Montgomery , G W , Kandler , C , McAdams , T A , Eley , T C , Gregory , A M , Saudino , K J , Dubois , L , Boivin , M , Haworth , C M A , Plomin , R , Oncel , S Y , Aliev , F , Stazi , M A , Fagnani , C , D'Ippolito , C , Craig , J M , Saffery , R , Siribaddana , S H , Hotopf , M , Sumathipala , A , Spector , T , Mangino , M , Lachance , G , Gatz , M , Butler , D A , Bayasgalan , G , Narandalai , D , Freitas , D L , Maia , J A , Harden , K P , Tucker-Drob , E M , Christensen , K , Skytthe , A , Kyvik , K O , Hong , C , Chong , Y , Derom , C A , Vlietinck , R F , Loos , R J F , Cozen , W , Hwang , A E , Mack , T M , He , M , Ding , X , Chang , B , Silberg , J L , Eaves , L J , Maes , H H , Cutler , T L , Hopper , J L , Aujard , K , Magnusson , P K E , Pedersen , N L , Aslan , A K D , Song , Y-M , Yang , S , Lee , K , Baker , L A , Tuvblad , C , Bjerregaard-Andersen , M , Beck-Nielsen , H , Sodemann , M , Heikkila , K , Tan , Q , Zhang , D , Swan , G E , Krasnow , R , Jang , K L , Knafo-Noam , A , Mankuta , D , Abramson , L , Lichtenstein , P , Krueger , R F , Mcgue , M , Pahlen , S , Tynelius , P , Duncan , G E , Buchwald , D , Corley , R P , Huibregtse , B M , Nelson , T L , Whitfield , K E , Franz , C E , Kremen , W S , Lyons , M J , Ooki , S , Brandt , I , Nilsen , T S , Inui , F , Watanabe , M , Bartels , M , van Beijsterveldt , T C E M , Wardle , J , Llewellyn , C H , Fisher , A , Rebato , E , Martin , N G , Iwatani , Y , Hayakawa , K , Rasmussen , F , Sung , J , Harris , J R , Willemsen , G , Busjahn , A , Goldberg , J H , Boomsma , D I , Hur , Y-M , Sorensen , T I A & Kaprio , J 2015 , ' The CODATwins Project : The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits ' , Twin Research and Human Genetics , vol. 18 , no. 4 , pp. 348-360 . https://doi.org/10.1017/thg.2015.29

Title: The CODATwins Project : The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits
Author: Silventoinen, Karri; Jelenkovic, Aline; Sund, Reijo; Honda, Chika; Aaltonen, Sari; Yokoyama, Yoshie; Tarnoki, Adam D.; Tarnoki, David L.; Ning, Feng; Ji, Fuling; Pang, Zengchang; Ordonana, Juan R.; Sanchez-Romera, Juan F.; Colodro-Conde, Lucia; Burt, S. Alexandra; Klump, Kelly L.; Medland, Sarah E.; Montgomery, Grant W.; Kandler, Christian; McAdams, Tom A.; Eley, Thalia C.; Gregory, Alice M.; Saudino, Kimberly J.; Dubois, Lise; Boivin, Michel; Haworth, Claire M. A.; Plomin, Robert; Oncel, Sevgi Y.; Aliev, Fazil; Stazi, Maria A.; Fagnani, Corrado; D'Ippolito, Cristina; Craig, Jeffrey M.; Saffery, Richard; Siribaddana, Sisira H.; Hotopf, Matthew; Sumathipala, Athula; Spector, Timothy; Mangino, Massimo; Lachance, Genevieve; Gatz, Margaret; Butler, David A.; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Freitas, Duarte L.; Maia, Jose Antonio; Harden, K. Paige; Tucker-Drob, Elliot M.; Christensen, Kaare; Skytthe, Axel; Kyvik, Kirsten O.; Hong, Changhee; Chong, Youngsook; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J. F.; Cozen, Wendy; Hwang, Amie E.; Mack, Thomas M.; He, Mingguang; Ding, Xiaohu; Chang, Billy; Silberg, Judy L.; Eaves, Lindon J.; Maes, Hermine H.; Cutler, Tessa L.; Hopper, John L.; Aujard, Kelly; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Aslan, Anna K. Dahl; Song, Yun-Mi; Yang, Sarah; Lee, Kayoung; Baker, Laura A.; Tuvblad, Catherine; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Heikkila, Kauko; Tan, Qihua; Zhang, Dongfeng; Swan, Gary E.; Krasnow, Ruth; Jang, Kerry L.; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Lichtenstein, Paul; Krueger, Robert F.; Mcgue, Matt; Pahlen, Shandell; Tynelius, Per; Duncan, Glen E.; Buchwald, Dedra; Corley, Robin P.; Huibregtse, Brooke M.; Nelson, Tracy L.; Whitfield, Keith E.; Franz, Carol E.; Kremen, William S.; Lyons, Michael J.; Ooki, Syuichi; Brandt, Ingunn; Nilsen, Thomas Sevenius; Inui, Fujio; Watanabe, Mikio; Bartels, Meike; van Beijsterveldt, Toos C. E. M.; Wardle, Jane; Llewellyn, Clare H.; Fisher, Abigail; Rebato, Esther; Martin, Nicholas G.; Iwatani, Yoshinori; Hayakawa, Kazuo; Rasmussen, Finn; Sung, Joohon; Harris, Jennifer R.; Willemsen, Gonneke; Busjahn, Andreas; Goldberg, Jack H.; Boomsma, Dorret I.; Hur, Yoon-Mi; Sorensen, Thorkild I. A.; Kaprio, Jaakko
Contributor: University of Helsinki, Department of Social Research (2010-2017)
University of Helsinki, Department of Social Research (2010-2017)
University of Helsinki, Department of Social Research (2010-2017)
University of Helsinki, Department of Public Health
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2015-08
Language: eng
Number of pages: 13
Belongs to series: Twin Research and Human Genetics
ISSN: 1832-4274
URI: http://hdl.handle.net/10138/234293
Abstract: For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m(2)) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.
Subject: twins
height
BMI
heritability
international comparisons
BODY-MASS INDEX
GENOME-WIDE ASSOCIATION
HUMAN OBESITY
ADOLESCENT DEVELOPMENT
SWEDISH TWIN
HEALTHY TWIN
ADULT HEIGHT
REARED APART
8 COUNTRIES
REGISTRY
3111 Biomedicine
3123 Gynaecology and paediatrics
3142 Public health care science, environmental and occupational health
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