Abnormal Brain Responses to Action Observation in Complex Regional Pain Syndrome

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http://hdl.handle.net/10138/234475

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Hotta , J , Saari , J , Koskinen , M , Hlushchuk , Y , Forss , N & Hari , R 2017 , ' Abnormal Brain Responses to Action Observation in Complex Regional Pain Syndrome ' , Journal of Pain , vol. 18 , no. 3 , pp. 255-265 . https://doi.org/10.1016/j.jpain.2016.10.017

Title: Abnormal Brain Responses to Action Observation in Complex Regional Pain Syndrome
Author: Hotta, Jaakko; Saari, Jukka; Koskinen, Miika; Hlushchuk, Yevhen; Forss, Nina; Hari, Riitta
Contributor: University of Helsinki, HUS Neurocenter
University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, HUS Neurocenter
Date: 2017-03
Language: eng
Number of pages: 11
Belongs to series: Journal of Pain
ISSN: 1526-5900
URI: http://hdl.handle.net/10138/234475
Abstract: Patients with complex regional pain syndrome (CRPS) display various abnormalities in central motor function, and their pain is intensified when they perform or just observe motor actions. In this study, we examined the abnormalities of brain responses to action observation in CRPS. We analyzed 3-T functional magnetic resonance images from 13 upper limb CRPS patients (all female, ages 31-58 years) and 13 healthy, age- and sex-matched control subjects. The functional magnetic resonance imaging data were acquired while the subjects viewed brief videos of hand actions shown in the first-person perspective. A pattern-classification analysis was applied to characterize brain areas where the activation pattern differed between CRPS patients and healthy subjects. Brain areas with statistically significant group differences (q <.05, false discovery rate-corrected) included the hand representation area in the sensorimotor cortex, inferior frontal gyrus, secondary somatosensory cortex, inferior parietal lobule, orbitofrontal cortex, and thalamus. Our findings indicate that CRPS impairs action observation by affecting brain areas related to pain processing and motor control. Perspective: This article shows that in CRPS, the observation of others' motor actions induces abnormal neural activity in brain areas essential for sensorimotor functions and pain. These results build the cerebral basis for action-observation impairments in CRPS. (C) 2016 by the American Pain Society
Subject: Action observation
chronic pain
CRPS
fMRI
multivoxel pattern analysis
TRANSCRANIAL MAGNETIC STIMULATION
REFLEX SYMPATHETIC DYSTROPHY
PRIMARY SOMATOSENSORY CORTEX
DIAGNOSTIC-CRITERIA
CYTOARCHITECTONIC MAPS
COGNITIVE CONTROL
MOTOR IMAGERY
HAND ACTIONS
CLASSIFICATION
3112 Neurosciences
3124 Neurology and psychiatry
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