Tenascin-C and fibronectin expression divide early stage tongue cancer into low- and high-risk groups

Show full item record



Permalink

http://hdl.handle.net/10138/236410

Citation

Sundquist , E , Kauppila , J H , Veijola , J , Mroueh , R , Lehenkari , P , Laitinen , S , Risteli , J , Soini , Y , Kosma , V-M , Sawazaki-Calone , I , Soares Macedo , C C , Bloigu , R , Coletta , R D & Salo , T 2017 , ' Tenascin-C and fibronectin expression divide early stage tongue cancer into low- and high-risk groups ' , British Journal of Cancer , vol. 116 , no. 5 , pp. 640-648 . https://doi.org/10.1038/bjc.2016.455

Title: Tenascin-C and fibronectin expression divide early stage tongue cancer into low- and high-risk groups
Author: Sundquist, Elias; Kauppila, Joonas H.; Veijola, Johanna; Mroueh, Rayan; Lehenkari, Petri; Laitinen, Saara; Risteli, Juha; Soini, Ylermi; Kosma, Veli-Matti; Sawazaki-Calone, Iris; Soares Macedo, Carolina Carneiro; Bloigu, Risto; Coletta, Ricardo D.; Salo, Tuula
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Clinicum
Date: 2017-02-28
Language: eng
Number of pages: 9
Belongs to series: British Journal of Cancer
ISSN: 0007-0920
URI: http://hdl.handle.net/10138/236410
Abstract: Background:Oral tongue squamous cell carcinoma (OTSCC) metastasises early, especially to regional lymph nodes. There is an ongoing debate on which early stage (T1-T2N0) patients should be treated with elective neck dissection. We need prognosticators for early stage tongue cancer. Methods: Mice immunisation with human mesenchymal stromal cells resulted in production of antibodies against tenascin-C (TNC) and fibronectin (FN), which were used to stain 178 (98 early stage), oral tongue squamous cell carcinoma samples. TenascinC and FN expression in the stroma (negative, moderate or abundant) and tumour cells (negative or positive) were assessed. Similar staining was obtained using corresponding commercial antibodies. Results: Expression of TNC and FN in the stroma, but not in the tumour cells, proved to be excellent prognosticators both in all stages and in early stage cases. Among early stages, when stromal TNC was negative, the 5-year survival rate was 88%. Correspondingly, when FN was negative, no cancer deaths were observed. Five-year survival rates for abundant expression of TNC and FN were 43% and 25%, respectively. Conclusions: Stromal TNC and, especially, FN expressions differentiate patients into low-and high-risk groups. Surgery alone of early stage primary tumours might be adequate when stromal FN is negative. Aggressive treatments should be considered when both TNC and FN are abundant.
Subject: tongue cancer
prognosis
mesenchymal stromal cell
tenascin-C
fibronectin
stroma
immunohistochemistry
tumour microenvironment
SQUAMOUS-CELL CARCINOMA
EXTRACELLULAR-MATRIX COMPONENTS
EARLY BREAST-CANCER
PROGNOSTIC-SIGNIFICANCE
COLORECTAL-CARCINOMA
ORAL-CANCER
CATHEPSIN-D
ACTIVIN-A
INVASION
PROGRESSION
3122 Cancers
313 Dentistry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
bjc2016455a.pdf 1.501Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record