Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease

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http://hdl.handle.net/10138/236747

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Ni , R , Gillberg , P-G , Bogdanovic , N , Viitanen , M , Myllykangas , L , Nennesmo , I , Langstrom , B & Nordberg , A 2017 , ' Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease ' , Alzheimer's & Dementia , vol. 13 , no. 4 , pp. 419-430 . https://doi.org/10.1016/j.jalz.2016.08.006

Title: Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease
Author: Ni, Ruiqing; Gillberg, Per-Goran; Bogdanovic, Nenad; Viitanen, Matti; Myllykangas, Liisa; Nennesmo, Inger; Langstrom, Bengt; Nordberg, Agneta
Other contributor: University of Helsinki, Medicum



Date: 2017-04
Language: eng
Number of pages: 12
Belongs to series: Alzheimer's & Dementia
ISSN: 1552-5260
DOI: https://doi.org/10.1016/j.jalz.2016.08.006
URI: http://hdl.handle.net/10138/236747
Abstract: Introduction: Amyloid imaging has been integrated into diagnostic criteria for Alzheimer's disease (AD). How amyloid tracers binding differ for different tracer structures and amyloid-beta aggregates in autosomal dominant AD (ADAD) and sporadic AD is unclear. Methods: Binding properties of different amyloid tracers were examined in brain homogenates from six ADAD with APPswe, PS1 M146V, and PS1 E Delta 9 mutations, 13 sporadic AD, and 14 control cases. Results: H-3-PIB, H-3-florbetaben, H-3-AZD2184, and BTA-1 shared a high-and a varying low-affinity binding site in the frontal cortex of sporadic AD. AZD2184 detected another binding site (affinity 33 nM) in the frontal cortex of ADAD. The H-3-AZD2184 and H-3-PIB binding were significantly higher in the striatum of ADAD compared to sporadic AD and control. Polyphenol resveratrol showed strongest inhibition on H-3-AZD84 binding followed by H-3-florbetaben and minimal on H-3-PIB. Discussion: This study implies amyloid tracers of different structures detect different sites on amyloid-beta fibrils or conformations. (C) 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Subject: Alzheimer's disease
Amyloid-beta
Autosomal dominant Alzheimer's disease
Positron emission tomography
Resveratrol
Pittsburgh compound B
AZD2184
Florbetaben
POSITRON-EMISSION-TOMOGRAPHY
MILD COGNITIVE IMPAIRMENT
PITTSBURGH COMPOUND B
A-BETA
SPASTIC PARAPARESIS
MUTATION CARRIERS
MOLECULAR-DYNAMICS
BRAIN-TISSUE
IN-VIVO
PET
3112 Neurosciences
3124 Neurology and psychiatry
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