Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults : Results from a meta-analysis and exploratory meta-regression analysis

Show full item record



Permalink

http://hdl.handle.net/10138/236994

Citation

Veronese , N , Cereda , E , Stubbs , B , Solmi , M , Luchini , C , Manzato , E , Sergi , G , Manu , P , Harris , T , Fontana , L , Strandberg , T , Amieva , H , Dumurgier , J , Elbaz , A , Tzourio , C , Eicholzer , M , Rohrmann , S , Moretti , C , D'Ascenzo , F , Quadri , G , Polidoro , A , Lourenco , R A , Moreira , V G , Sanchis , J , Scotti , V , Maggi , S & Correll , C U 2017 , ' Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults : Results from a meta-analysis and exploratory meta-regression analysis ' , Ageing research reviews , vol. 35 , pp. 63-73 . https://doi.org/10.1016/j.arr.2017.01.003

Title: Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults : Results from a meta-analysis and exploratory meta-regression analysis
Author: Veronese, Nicola; Cereda, Emanuele; Stubbs, Brendon; Solmi, Marco; Luchini, Claudio; Manzato, Enzo; Sergi, Giuseppe; Manu, Peter; Harris, Tamara; Fontana, Luigi; Strandberg, Timo; Amieva, Helene; Dumurgier, Julien; Elbaz, Alexis; Tzourio, Christophe; Eicholzer, Monika; Rohrmann, Sabine; Moretti, Claudio; D'Ascenzo, Fabrizio; Quadri, Giorgio; Polidoro, Alessandro; Lourenco, Roberto Alves; Moreira, Virgilio Garcia; Sanchis, Juan; Scotti, Valeria; Maggi, Stefania; Correll, Christoph U.
Contributor: University of Helsinki, University of Helsinki
Date: 2017-05
Language: eng
Number of pages: 11
Belongs to series: Ageing research reviews
ISSN: 1568-1637
URI: http://hdl.handle.net/10138/236994
Abstract: Frailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs)+/- 95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total of 31,343 participants were meta-analyzed. Using estimates from 10 cross-sectional cohorts, both frailty and pre-frailty were associated with higher odds of CVD than robust participants. Longitudinal data were obtained from 6 prospective cohort studies. After a median follow-up of 4.4 years, we identified an increased risk for faster onset of any type CVD in the frail (HR= 1.70 [95%CI, 1.18-2.45]; I-2 = 66%) and pre-frail (HR= 1.23 [95%CI, 1.07-1.36]; I-2 = 67%) vs. robust groups. Similar results were apparent for time to CVD mortality in the frail and pre-frail groups. In conclusion, frailty and pre-frailty constitute addressable and independent risk factors for CVD in older adults. (C) 2017 Elsevier B.V. All rights reserved.
Subject: Frailty
Cardiovascular disease
Meta-analysis
CORONARY-HEART-DISEASE
WOMENS-HEALTH
OXIDATIVE STRESS
ELDERLY-PATIENTS
MIDLIFE OBESITY
AGE FRAILTY
FOLLOW-UP
ASSOCIATION
MEN
POPULATION
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S1568163716302318_main.pdf 1.246Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record