Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan

Show simple item record Harris, Vanessa Ali, Asad Fuentes, Susana Korpela, Katri Kazi, Momin Tate, Jacqueline Parashar, Umesh Wiersinga, W. Joost Giaquinto, Carlo de Weerth, Carolina de Vos, Willem M. 2018-07-13T08:18:01Z 2018-07-13T08:18:01Z 2018
dc.identifier.citation Harris , V , Ali , A , Fuentes , S , Korpela , K , Kazi , M , Tate , J , Parashar , U , Wiersinga , W J , Giaquinto , C , de Weerth , C & de Vos , W M 2018 , ' Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan ' , Gut Microbes , vol. 9 , no. 2 , pp. 93-101 .
dc.identifier.other PURE: 109706086
dc.identifier.other PURE UUID: b984b35d-8150-40b3-8791-7e9e4f2b5f7e
dc.identifier.other WOS: 000435713000001
dc.identifier.other Scopus: 85030166240
dc.description.abstract Rotavirus (RV) is the leading cause of diarrhea-related death in children worldwide and ninety-five percent of rotavirus deaths occur in Africa and Asia. Rotavirus vaccines (RVV) can dramatically reduce RV deaths, but have low efficacy in low-income settings where they are most needed. The intestinal microbiome may contribute to this decreased RVV efficacy. This pilot study hypothesizes that infants' intestinal microbiota composition correlates with RVV immune responses and that RVV responders have different gut microbiota as compared to non-responders. We conducted a nested, matched case-control study comparing the pre-vaccination intestinal microbiota composition between 10 6-week old Pakistani RVV-responders, 10 6-week old Pakistani RVV non-responders, and 10 healthy Dutch infants. RVV response was defined as an Immunoglobulin A of >= 20 IU/mL following Rotarix (TM)(RV1) vaccination in an infant with aprevaccination IgA RV1 response correlated with a higher relative abundance of bacteria belonging to Clostridium cluster XI and Proteobacteria, including bacteria related to Serratia and Escherichia coli. Remarkably, abundance of these Proteobacteria was also significantly higher in Dutch infants when compared to RV1-non-responders in Pakistan. This small but carefully matched study showed the intestinal microbiota composition to correlate with RV1 seroconversion in Pakistan infants, identifying signatures shared with healthy Dutch infants. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Gut Microbes
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject intestinal microbes
dc.subject seroconversion
dc.subject rotavirus vaccine
dc.subject vaccine immunogenicity
dc.subject 1ST 2 YEARS
dc.subject DOUBLE-BLIND
dc.subject EFFICACY
dc.subject MONOVALENT
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 1183 Plant biology, microbiology, virology
dc.title Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan en
dc.type Article
dc.contributor.organization Department of Bacteriology and Immunology
dc.contributor.organization Medicum
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1949-0976
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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