A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis

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http://hdl.handle.net/10138/238982

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JSCRG & TSRHCCG 2018 , ' A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis ' , Scientific Reports , vol. 8 , 11575 . https://doi.org/10.1038/s41598-018-29011-7

Title: A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis
Author: JSCRG; TSRHCCG
Date: 2018-08-01
Language: eng
Number of pages: 8
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/238982
Abstract: Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associated with AIS. Among them is a locus on chromosome 6q24.1 that we identified by a GWAS in a Japanese cohort. The locus is represented by rs6570507 located within GPR126. To ensure the association of rs6570507 with AIS, we conducted a meta-analysis using eight cohorts from East Asia, Northern Europe and USA. The analysis included a total of 6,873 cases and 38,916 controls and yielded significant association (combined P = 2.95 x 10(-20); odds ratio = 1.22), providing convincing evidence of the worldwide association between rs6570507 and AIS susceptibility. In silico analyses strongly suggested that GPR126 is a susceptibility gene at this locus.
Subject: GENOME-WIDE ASSOCIATION
BONE-MINERAL DENSITY
MACULAR DEGENERATION
RARE VARIANTS
LBX1
GENE
EPIDEMIOLOGY
CHINESE
RISK
BODY
3111 Biomedicine
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