Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

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http://hdl.handle.net/10138/239655

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NHLBI TOPMED Lipids Working Grp 2018 , ' Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries ' , Nature Communications , vol. 9 , 2606 . https://doi.org/10.1038/s41467-018-04668-w

Title: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries
Author: NHLBI TOPMED Lipids Working Grp
Contributor organization: Institute for Molecular Medicine Finland
Samuli Olli Ripatti / Principal Investigator
University of Helsinki
Centre of Excellence in Complex Disease Genetics
Clinicum
Doctoral Programme in Population Health
Department of Public Health
Complex Disease Genetics
Date: 2018-07-04
Language: eng
Number of pages: 14
Belongs to series: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-018-04668-w
URI: http://hdl.handle.net/10138/239655
Abstract: Lipoprotein(a), Lp(a), is a modified low- density lipoprotein particle that contains apolipoprotein( a), encoded by LPA, and is a highly heritable, causal risk factor for cardiovascular diseases that varies in concentrations across ancestries. Here, we use deep-coverage whole genome sequencing in 8392 individuals of European and African ancestry to discover and interpret both single-nucleotide variants and copy number (CN) variation associated with Lp(a). We observe that genetic determinants between Europeans and Africans have several unique determinants. The common variant rs12740374 associated with Lp(a) cholesterol is an eQTL for SORT1 and independent of LDL cholesterol. Observed associations of aggregates of rare non-coding variants are largely explained by LPA structural variation, namely the LPA kringle IV 2 (KIV2)-CN. Finally, we find that LPA risk genotypes confer greater relative risk for incident atherosclerotic cardiovascular diseases compared to directly measured Lp(a), and are significantly associated with measures of subclinical atherosclerosis in African Americans.
Description: Correction: Volume: 9, Article Number: 3493 DOI: 10.1038/s41467-018-05975-y Published: AUG 23 2018
Subject: CORONARY-HEART-DISEASE
WIDE ASSOCIATION
GENETIC-VARIANTS
CARDIOVASCULAR-DISEASE
COMPONENTS-ANALYSIS
POPULATION-SCALE
RARE VARIANTS
LOW-FREQUENCY
RISK-FACTOR
CHOLESTEROL
3111 Biomedicine
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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