A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents

Show full item record



Permalink

http://hdl.handle.net/10138/244927

Citation

Zusinaite , E , Ianevski , A , Niukkanen , D , Poranen , M M , Bjoras , M , Afset , J E , Tenson , T , Velagapudi , V , Merits , A & Kainov , D E 2018 , ' A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents ' , Viruses-Basel , vol. 10 , no. 8 , 423 . https://doi.org/10.3390/v10080423

Title: A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents
Author: Zusinaite, Eva; Ianevski, Aleksandr; Niukkanen, Diana; Poranen, Minna M.; Bjoras, Magnar; Afset, Jan Egil; Tenson, Tanel; Velagapudi, Vidya; Merits, Andres; Kainov, Denis E.
Contributor: University of Helsinki, Molecular and Integrative Biosciences Research Programme
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, University of Tartu
Date: 2018-08
Language: eng
Number of pages: 13
Belongs to series: Viruses-Basel
ISSN: 1999-4915
URI: http://hdl.handle.net/10138/244927
Abstract: There are dozens of approved, investigational and experimental antiviral agents. Many of these agents cause serious side effects, which can only be revealed after drug administration. Identification of the side effects prior to drug administration is challenging. Here we describe an ex vivo approach for studying immuno- and neuro-modulatory properties of antiviral agents, which may be associated with potential side effects of these therapeutics. The current approach combines drug toxicity/efficacy tests and transcriptomics, which is followed by mRNA, cytokine and metabolite profiling. We demonstrated the utility of this approach with several examples of antiviral agents. We also showed that the approach can utilize different immune stimuli and cell types. It can also include other omics techniques, such as genomics and epigenomics, to allow identification of individual markers associated with adverse reactions to antivirals with immuno- and neuro-modulatory properties.
Subject: virus
antiviral agent
drug target
drug side effect
innate immunity
precision medicine
systems biology
INFECTION IN-VITRO
A VIRUS-INFECTION
ANTIRETROVIRAL THERAPY
SALIPHENYLHALAMIDE
DISEASE
GEMCITABINE
OBATOCLAX
HIV
METABOLISM
AMANTADINE
1183 Plant biology, microbiology, virology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
viruses_10_8_00423.pdf 4.725Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record