The Psoriasis Risk Allele HLA-C*06 : 02 Shows Evidence of Association with Chronic or Recurrent Streptococcal Tonsillitis

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Haapasalo , K , Koskinen , L L E , Suvilehto , J , Jousilahti , P , Wolin , A , Suomela , S , Trembath , R , Barker , J , Vuopio , J , Kere , J , Jokiranta , T S & Saavalainen , P 2018 , ' The Psoriasis Risk Allele HLA-C*06 : 02 Shows Evidence of Association with Chronic or Recurrent Streptococcal Tonsillitis ' , Infection and Immunity , vol. 86 , no. 10 , ARTN e00304-18 . https://doi.org/10.1128/IAI.00304-18

Title: The Psoriasis Risk Allele HLA-C*06 : 02 Shows Evidence of Association with Chronic or Recurrent Streptococcal Tonsillitis
Author: Haapasalo, Karita; Koskinen, Lotta L. E.; Suvilehto, Jari; Jousilahti, Pekka; Wolin, Annika; Suomela, Sari; Trembath, Richard; Barker, Jonathan; Vuopio, Jaana; Kere, Juha; Jokiranta, T. Sakari; Saavalainen, Päivi
Contributor organization: Research Programs Unit
Immunobiology Research Program
Department of Bacteriology and Immunology
University of Helsinki
Medicum
Department of Medical and Clinical Genetics
Clinicum
Korva-, nenä- ja kurkkutautien klinikka
Department of Dermatology, Allergology and Venereology
Research Programme for Molecular Neurology
Juha Kere / Principal Investigator
Immunomics
Date: 2018-10
Language: eng
Number of pages: 9
Belongs to series: Infection and Immunity
ISSN: 0019-9567
DOI: https://doi.org/10.1128/IAI.00304-18
URI: http://hdl.handle.net/10138/248075
Abstract: Pharyngeal tonsillitis is one of the most common upper respiratory tract infections, and group A streptococcus is the most important bacterial pathogen causing it. While most patients experience tonsillitis only rarely, a subset of patients suffers from recurrent or chronic tonsillitis or pharyngitis. The predisposing factors for recurring or chronic forms of this disease are not yet fully understood, but genetic predisposition has been suggested. A genetic association study using Illumina's Immunochip single-nucleotide polymorphism (SNP) array was performed to search for new genetic biomarkers in pharyngeal tonsillitis. More than 100,000 SNPs relevant to immune-mediated diseases were analyzed in a cohort of 95 patients subjected to tonsillectomy due to recurrent/chronic tonsillitis and 504 controls. Genetic association between the cases and controls showed strongest association with two peaks in the HLA locus (odds ratio [OR], 3.7 to 4.7; P = 4.9 x 10(-6) to 5.7 x 10(-6)). Further analysis with imputed classical HLA alleles suggested the known psoriasis risk allele HLA-C*06:02 as a risk factor for tonsillitis (P = 4.8 x 10(-4); OR, 2.3). In addition, the imputed HLA haplotype HLA-C*06:02/HLA-B*57:01, a reported risk haplotype in psoriasis, had the strongest risk for tonsillitis (P = 3.2 x 10(-4); OR, 6.5). These findings further support the previously reported link between streptococcal throat infections and psoriasis.
Subject: group A streptococcus
psoriasis
tonsillitis
GENOME-WIDE ASSOCIATION
THROAT INFECTIONS
PLAQUE PSORIASIS
IN-VITRO
FACTOR-H
T-CELLS
HLA-CW6
PHARYNGITIS
DISEASE
TONSILLECTOMY
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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