A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

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FINNPEC 2018 , ' A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants ' , Scientific Reports , vol. 8 , 14616 . https://doi.org/10.1038/s41598-018-32804-5

Title: A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants
Author: FINNPEC
Contributor organization: Pregnancy and Genes
Department of Medical and Clinical Genetics
Research Programs Unit
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
Institute for Molecular Medicine Finland
Helsinki Institute of Life Science HiLIFE
Genomics of Neurological and Neuropsychiatric Disorders
Date: 2018-10-02
Language: eng
Number of pages: 12
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-018-32804-5
URI: http://hdl.handle.net/10138/251514
Abstract: Preeclampsia (PE) is a complex pregnancy disorder. It is not extensively known how the metabolic alterations of PE women contribute to the metabolism of newborn. We applied liquid chromatography-mass spectrometry (LC-MS) based non-targeted meta bolomics to determine whether the metabolic profile of plasma from umbilical cord differs between infants born to PE and non-PE pregnancies in the FINNPEC study. Cord plasma was available from 42 newborns born from PE and 53 from non-PE pregnancies. 133 molecular features differed between PE and non-PE newborns after correction for multiple testing. Decreased levels of 4-pyridoxic acid were observed in the cord plasma samples of PE newborns when compared to non-PE newborns. Compounds representing following areas of metabolism were increased in the cord plasma of PE newborns: urea and creatine metabolism; carnitine biosynthesis and acylcarnitines; putrescine metabolites; tryptophan metabolism and phosphatidylcholines. To our knowledge, this study is the first one to apply LC-MS based meta bolomics in cord plasma of PE newborns. We demonstrate that this strategy provides a global picture of the widespread metabolic alterations associated with PE and particularly the elevated levels of carnitine precursors and trimethylated compounds appear to be associated with PE at birth.
Subject: HUMAN-PLACENTA
ENDOTHELIAL-CELLS
TRANSPORTER OCTN2
FETAL METABOLISM
NORMAL-PREGNANCY
OXIDE PATHWAY
BIRTH-WEIGHT
BLOOD
BUTYROBETAINE
METABOLOMICS
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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