Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts

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Piirtola , M , Jelenkovic , A , Latvala , A , Sund , R , Korhonen , M T , Kaprio , J , Silventoinen , K & collaboration group , CODAT 2018 , ' Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts ' , PLoS One , vol. 13 , no. 7 , 0200140 . https://doi.org/10.1371/journal.pone.0200140

Title: Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts
Author: Piirtola, Maarit; Jelenkovic, Aline; Latvala, Antti; Sund, Reijo; Korhonen, Maila Tellervo; Kaprio, Jaakko; Silventoinen, Karri; collaboration group, CODATwins
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Population Research Unit (PRU)
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Research Units of the Faculty of Social Sciences
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Academic Disciplines of the Faculty of Social Sciences
Date: 2018-07-12
Language: eng
Number of pages: 17
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/252784
Abstract: Background Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because smokers and non-smokers may differ in genetic and environmental family background, we analysed data from twin pairs in which the co-twins differed by their smoking behaviour to evaluate if the association between smoking and body mass index (BMI) remains after controlling for family background. Methods and findings The international CODATwins database includes information on smoking and BMI measured between 1960 and 2012 from 156,593 twin individuals 18–69 years of age. Individual-based data (230,378 measurements) and data of smoking discordant twin pairs (altogether 30,014 pairwise measurements, 36% from monozygotic [MZ] pairs) were analysed with linear fixed-effects regression models by 10-year periods. In MZ pairs, the smoking co-twin had, on average, 0.57 kg/m2 lower BMI in men (95% confidence interval (CI): 0.49, 0.70) and 0.65 kg/m2 lower BMI in women (95% CI: 0.52, 0.79) than the never smoking co-twin. Former smokers had 0.70 kg/m2 higher BMI among men (95% CI: 0.63, 0.78) and 0.62 kg/m2 higher BMI among women (95% CI: 0.51, 0.73) than their currently smoking MZ co-twins. Little difference in BMI was observed when comparing former smoking co-twins with their never smoking MZ co-twins (0.13 kg/m2, 95% CI 0.04, 0.23 among men; -0.04 kg/m2, 95% CI -0.16, 0.09 among women). The associations were similar within dizygotic pairs and when analysing twins as individuals. The observed series of cross-sectional associations were independent of sex, age, and measurement decade. Conclusions Smoking is associated with lower BMI and smoking cessation with higher BMI. However, the net effect of smoking and subsequent cessation on weight development appears to be minimal, i.e. never more than an average of 0.7 kg/m2.
Subject: 3142 Public health care science, environmental and occupational health
WEIGHT-GAIN
CAUSAL INFERENCE
METAANALYSIS
CIGARETTE
CESSATION
BEHAVIOR
SMOKERS
OBESITY
TRAITS
ENVIRONMENT
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