Regulation of Renal Differentiation by Trophic Factors

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Kurtzeborn , K , Cebrian , C & Kuure , S 2018 , ' Regulation of Renal Differentiation by Trophic Factors ' , Frontiers in Physiology , vol. 9 , 1588 . https://doi.org/10.3389/fphys.2018.01588

Title: Regulation of Renal Differentiation by Trophic Factors
Author: Kurtzeborn, Kristen; Cebrian, Cristina; Kuure, Satu
Contributor: University of Helsinki, Helsinki Institute of Life Science HiLIFE
University of Helsinki, Kidney development
Date: 2018-11-12
Language: eng
Number of pages: 16
Belongs to series: Frontiers in Physiology
ISSN: 1664-042X
URI: http://hdl.handle.net/10138/265102
Abstract: Classically, trophic factors are considered as proteins which support neurons in their growth, survival, and differentiation. However, most neurotrophic factors also have important functions outside of the nervous system. Especially essential renal growth and differentiation regulators are glial cell line-derived neurotrophic factor (GDNF), bone morphogenetic proteins (BMPs), and fibroblast growth factors (FGFs). Here we discuss how trophic factor-induced signaling contributes to the control of ureteric bud (UB) branching morphogenesis and to maintenance and differentiation of nephrogenic mesenchyme in embryonic kidney. The review includes recent advances in trophic factor functions during the guidance of branching morphogenesis and self-renewal versus differentiation decisions, both of which dictate the control of kidney size and nephron number. Creative utilization of current information may help better recapitulate renal differentiation in vitro, but it is obvious that significantly more basic knowledge is needed for development of regeneration-based renal therapies.
Subject: receptor tyrosin kinase
development
kidney
intracelluar signaling
renal differentiation
morphogenesis
kidney morphogenesis
FIBROBLAST-GROWTH-FACTOR
DEVELOPING MOUSE KIDNEY
NEPHRON PROGENITOR POPULATION
MICE LACKING GDNF
RECEPTOR TYROSINE KINASE
URETERAL BUD DEVELOPMENT
PLURIPOTENT STEM-CELLS
C-RET PROTOONCOGENE
LOWER URINARY-TRACT
BRANCHING MORPHOGENESIS
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
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