Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

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Thery , C , Witwer , K W , Aikawa , E , Jose Alcaraz , M , Anderson , J D , Andriantsitohaina , R , Antoniou , A , Arab , T , Archer , F , Atkin-Smith , G K , Ayre , D C , Bach , J-M , Bachurski , D , Baharvand , H , Balaj , L , Baldacchino , S , Bauer , N N , Baxter , A A , Bebawy , M , Beckham , C , Zavec , A B , Benmoussa , A , Berardi , A C , Bergese , P , Bielska , E , Blenkiron , C , Bobis-Wozowicz , S , Boilard , E , Boireau , W , Bongiovanni , A , Borras , F E , Bosch , S , Boulanger , C M , Breakefield , X , Breglio , A M , Brennan , M A , Brigstock , D R , Brisson , A , Broekman , M L D , Bromberg , J F , Bryl-Gorecka , P , Buch , S , Buck , A H , Burger , D , Busatto , S , Buschmann , D , Bussolati , B , Buzas , E , Byrd , J B , Camussi , G , Carter , D R F , Caruso , S , Chamley , L W , Chang , Y-T , Chaudhuri , A D , Chen , C , Chen , S , Cheng , L , Chin , A R , Clayton , A , Clerici , S P , Cocks , A , Cocucci , E , Coffey , R J , Cordeiro-da-Silva , A , Couch , Y , Coumans , F A W , Coyle , B , Crescitelli , R , Criado , M F , D'Souza-Schorey , C , Das , S , de Candia , P , De Santana Junior , E F , De Wever , O , del Portillo , H A , Demaret , T , Deville , S , Devitt , A , Dhondt , B , Di Vizio , D , Dieterich , L C , Dolo , V , Dominguez Rubio , A P , Dominici , M , Dourado , M R , Driedonks , T A P , Duarte , F , Duncan , H M , Eichenberger , R M , Ekstrom , K , Andaloussi , S E L , Elie-Caille , C , Erdbrugger , U , Falcon-Perez , J M , Fatima , F , Fish , J E , Flores-Bellver , M , Forsonits , A , Frelet-Barrand , A , Fricke , F , Fuhrmann , G , Gabrielsson , S , Gamez-Valero , A , Gardiner , C , Gaertner , K , Gaudin , R , Gho , Y S , Giebel , B , Gilbert , C , Gimona , M , Giusti , I , Goberdhan , D C , Goergens , A , Gorski , S M , Greening , D W , Gross , J C , Gualerzi , A , Gupta , G N , Gustafson , D , Handberg , A , Haraszti , R A , Harrison , P , Hegyesi , H , Hendrix , A , Hill , A F , Hochberg , F H , Hoffmann , K F , Holder , B , Holthofer , H , Hosseinkhani , B , Hu , G , Huang , Y , Huber , V , Hunt , S , Ibrahim , A G-E , Ikezu , T , Inal , J M , Isin , M , Ivanova , A , Jackson , H K , Jacobsen , S , Jay , S M , Jayachandran , M , Jenster , G , Jiang , L , Johnson , S M , Jones , J C , Jong , A , Jovanovic-Talisman , T , Jung , S , Kalluri , R , Kano , S , Kaur , S , Kawamura , Y , Keller , E T , Khamari , D , Khomyakova , E , Khvorova , A , Kierulf , P , Kim , K P , Kislinger , T , Klingeborn , M , Klinke , D J , Kornek , M , Kosanovic , M M , Kovacs , A F , Kraemer-Albers , E-M , Krasemann , S , Krause , M , Kurochkin , I , Kusuma , G D , Kuypers , S , Laitinen , S , Langevin , S M , Languino , L R , Lannigan , J , Lasser , C , Laurent , L C , Lavieu , G , Lazaro-Ibanez , E , Le Lay , S , Lee , M-S , Lee , Y X F , Lemos , D S , Lenassi , M , Leszczynska , A , Li , I T S , Liao , K , Libregts , S F , Ligeti , E , Lim , R , Lim , S K , Line , A , Linnemannstoens , K , Llorente , A , Lombard , C A , Lorenowicz , M J , Lorincz , A M , Lotvall , J , Lovett , J , Lowry , M C , Loyer , X , Lu , Q , Lukomska , B , Lunavat , T R , Maas , S L N , Malhi , H , Marcilla , A , Mariani , J , Mariscal , J , Martens-Uzunova , E S , Martin-Jaular , L , Martinez , M C , Martins , V R , Mathieu , M , Mathivanan , S , Maugeri , M , McGinnis , L K , McVey , M J , Meckes , D G , Meehan , K L , Mertens , I , Minciacchi , V R , Moller , A , Jorgensen , M M , Morales-Kastresana , A , Morhayim , J , Mullier , F , Muraca , M , Musante , L , Mussack , V , Muth , D C , Myburgh , K H , Najrana , T , Nawaz , M , Nazarenko , I , Nejsum , P , Neri , C , Neri , T , Nieuwland , R , Nimrichter , L , Nolan , J P , Hoen , E N M N , Hooten , N N , O'Driscoll , L , O'Grady , T , O'Loghlen , A , Ochiya , T , Olivier , M , Ortiz , A , Ortiz , L A , Osteikoetxea , X , Ostegaard , O , Ostrowski , M , Park , J , Pegtel , D M , Peinado , H , Perut , F , Pfaffl , M W , Phinney , D G , Pieters , B C H , Pink , R C , Pisetsky , D S , von Strandmann , E P , Polakovicova , I , Poon , I K H , Powell , B H , Prada , I , Pulliam , L , Quesenberry , P , Radeghieri , A , Raffai , R L , Raimondo , S , Rak , J , Ramirez , M , Raposo , G , Rayyan , M S , Regev-Rudzki , N , Ricklefs , F L , Robbins , P D , Roberts , D D , Rodrigues , S C , Rohde , E , Rome , S , Rouschop , K M A , Rughetti , A , Russell , A E , Saa , P , Sahoo , S , Salas-Huenuleo , E , Sanchez , C , Saugstad , J A , Saul , M J , Schiffelers , R M , Schneider , R , Schoyen , T H , Scott , A , Shahaj , E , Sharma , S , Shatnyeva , O , Shekari , F , Shelke , G V , Shetty , A K , Shiba , K , Siljander , P R-M , Silva , A M , Skowronek , A , Snyder , O L , Soares , R P , Sodar , B W , Soekmadji , C , Sotillo , J , Stahl , P D , Stoorvogel , W , Stott , S L , Strasser , E F , Swift , S , Tahara , H , Tewari , M , Timms , K , Tiwari , S , Tixeira , R , Tkach , M , Toh , W S , Tomasini , R , Torrecilhas , A C , Pablo Tosar , J , Toxavidis , V , Urbanelli , L , Vader , P , van Balkom , B W M , van der Grein , S G , Van Deun , J , van Herwijnen , M J C , Van Keuren-Jensen , K , van Niel , G , van Royen , M E , van Wijnen , A J , Helena Vasconcelos , M , Vechetti , I J , Veit , T D , Vella , L J , Velot , E , Verweij , F J , Vestad , B , Vinas , J L , Visnovitz , T , Vukman , K V , Wahlgren , J , Watson , D C , Wauben , M H M , Weaver , A , Webber , J P , Weber , V , Wehman , A M , Weiss , D J , Welsh , J A , Wendt , S , Wheelock , A M , Wiener , Z , Witte , L , Wolfram , J , Xagorari , A , Xander , P , Xu , J , Yan , X , Yanez-Mo , M , Yin , H , Yuana , Y , Zappulli , V , Zarubova , J , Zekas , V , Zhang , J , Zhao , Z , Zheng , L , Zheutlin , A R , Zickler , A M , Zimmermann , P , Zivkovic , A M , Zocco , D & Zuba-Surma , E K 2018 , ' Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines ' , Journal of Extracellular Vesicles , vol. 7 , no. 1 , 1535750 . https://doi.org/10.1080/20013078.2018.1535750

Title: Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Author: Thery, Clotilde; Witwer, Kenneth W.; Aikawa, Elena; Jose Alcaraz, Maria; Anderson, Johnathon D.; Andriantsitohaina, Ramaroson; Antoniou, Anna; Arab, Tanina; Archer, Fabienne; Atkin-Smith, Georgia K.; Ayre, D. Craig; Bach, Jean-Marie; Bachurski, Daniel; Baharvand, Hossein; Balaj, Leonora; Baldacchino, Shawn; Bauer, Natalie N.; Baxter, Amy A.; Bebawy, Mary; Beckham, Carla; Zavec, Apolonija Bedina; Benmoussa, Abderrahim; Berardi, Anna C.; Bergese, Paolo; Bielska, Ewa; Blenkiron, Cherie; Bobis-Wozowicz, Sylwia; Boilard, Eric; Boireau, Wilfrid; Bongiovanni, Antonella; Borras, Francesc E.; Bosch, Steffi; Boulanger, Chantal M.; Breakefield, Xandra; Breglio, Andrew M.; Brennan, Meadhbh A.; Brigstock, David R.; Brisson, Alain; Broekman, Marike L. D.; Bromberg, Jacqueline F.; Bryl-Gorecka, Paulina; Buch, Shilpa; Buck, Amy H.; Burger, Dylan; Busatto, Sara; Buschmann, Dominik; Bussolati, Benedetta; Buzas, Edit; Byrd, James Bryan; Camussi, Giovanni; Carter, David R. F.; Caruso, Sarah; Chamley, Lawrence W.; Chang, Yu-Ting; Chaudhuri, Amrita Datta; Chen, Chihchen; Chen, Shuai; Cheng, Lesley; Chin, Andrew R.; Clayton, Aled; Clerici, Stefano P.; Cocks, Alex; Cocucci, Emanuele; Coffey, Robert J.; Cordeiro-da-Silva, Anabela; Couch, Yvonne; Coumans, Frank A. W.; Coyle, Beth; Crescitelli, Rossella; Criado, Miria Ferreira; D'Souza-Schorey, Crislyn; Das, Saumya; de Candia, Paola; De Santana Junior, Eliezer F.; De Wever, Olivier; del Portillo, Hernando A.; Demaret, Tanguy; Deville, Sarah; Devitt, Andrew; Dhondt, Bert; Di Vizio, Dolores; Dieterich, Lothar C.; Dolo, Vincenza; Dominguez Rubio, Ana Paula; Dominici, Massimo; Dourado, Mauricio R.; Driedonks, Tom A. P.; Duarte, Filipe; Duncan, Heather M.; Eichenberger, Ramon M.; Ekstrom, Karin; Andaloussi, Samir E. L.; Elie-Caille, Celine; Erdbrugger, Uta; Falcon-Perez, Juan M.; Fatima, Farah; Fish, Jason E.; Flores-Bellver, Miguel; Forsonits, Andras; Frelet-Barrand, Annie; Fricke, Fabia; Fuhrmann, Gregor; Gabrielsson, Susanne; Gamez-Valero, Ana; Gardiner, Chris; Gaertner, Kathrin; Gaudin, Raphael; Gho, Yong Song; Giebel, Bernd; Gilbert, Caroline; Gimona, Mario; Giusti, Ilaria; Goberdhan, Deborah C.; Goergens, Andre; Gorski, Sharon M.; Greening, David W.; Gross, Julia Christina; Gualerzi, Alice; Gupta, Gopal N.; Gustafson, Dakota; Handberg, Aase; Haraszti, Reka A.; Harrison, Paul; Hegyesi, Hargita; Hendrix, An; Hill, Andrew F.; Hochberg, Fred H.; Hoffmann, Karl F.; Holder, Beth; Holthofer, Harry; Hosseinkhani, Baharak; Hu, Guoku; Huang, Yiyao; Huber, Veronica; Hunt, Stuart; Ibrahim, Ahmed Gamal-Eldin; Ikezu, Tsuneya; Inal, Jameel M.; Isin, Mustafa; Ivanova, Alena; Jackson, Hannah K.; Jacobsen, Soren; Jay, Steven M.; Jayachandran, Muthuvel; Jenster, Guido; Jiang, Lanzhou; Johnson, Suzanne M.; Jones, Jennifer C.; Jong, Ambrose; Jovanovic-Talisman, Tijana; Jung, Stephanie; Kalluri, Raghu; Kano, Shin-ichi; Kaur, Sukhbir; Kawamura, Yumi; Keller, Evan T.; Khamari, Delaram; Khomyakova, Elena; Khvorova, Anastasia; Kierulf, Peter; Kim, Kwang Pyo; Kislinger, Thomas; Klingeborn, Mikael; Klinke, David J.; Kornek, Miroslaw; Kosanovic, Maja M.; Kovacs, Arpad Ferenc; Kraemer-Albers, Eva-Maria; Krasemann, Susanne; Krause, Mirja; Kurochkin, Igor; Kusuma, Gina D.; Kuypers, Soren; Laitinen, Saara; Langevin, Scott M.; Languino, Lucia R.; Lannigan, Joanne; Lasser, Cecilia; Laurent, Louise C.; Lavieu, Gregory; Lazaro-Ibanez, Elisa; Le Lay, Soazig; Lee, Myung-Shin; Lee, Yi Xin Fiona; Lemos, Debora S.; Lenassi, Metka; Leszczynska, Aleksandra; Li, Isaac T. S.; Liao, Ke; Libregts, Sten F.; Ligeti, Erzsebet; Lim, Rebecca; Lim, Sai Kiang; Line, Aija; Linnemannstoens, Karen; Llorente, Alicia; Lombard, Catherine A.; Lorenowicz, Magdalena J.; Lorincz, Akos M.; Lotvall, Jan; Lovett, Jason; Lowry, Michelle C.; Loyer, Xavier; Lu, Quan; Lukomska, Barbara; Lunavat, Taral R.; Maas, Sybren L. N.; Malhi, Harmeet; Marcilla, Antonio; Mariani, Jacopo; Mariscal, Javier; Martens-Uzunova, Elena S.; Martin-Jaular, Lorena; Martinez, M. Carmen; Martins, Vilma Regina; Mathieu, Mathilde; Mathivanan, Suresh; Maugeri, Marco; McGinnis, Lynda K.; McVey, Mark J.; Meckes, David G.; Meehan, Katie L.; Mertens, Inge; Minciacchi, Valentina R.; Moller, Andreas; Jorgensen, Malene Moller; Morales-Kastresana, Aizea; Morhayim, Jess; Mullier, Francois; Muraca, Maurizio; Musante, Luca; Mussack, Veronika; Muth, Dillon C.; Myburgh, Kathryn H.; Najrana, Tanbir; Nawaz, Muhammad; Nazarenko, Irina; Nejsum, Peter; Neri, Christian; Neri, Tommaso; Nieuwland, Rienk; Nimrichter, Leonardo; Nolan, John P.; Hoen, Esther N. M. Nolte-'t; Hooten, Nicole Noren; O'Driscoll, Lorraine; O'Grady, Tina; O'Loghlen, Ana; Ochiya, Takahiro; Olivier, Martin; Ortiz, Alberto; Ortiz, Luis A.; Osteikoetxea, Xabier; Ostegaard, Ole; Ostrowski, Matias; Park, Jaesung; Pegtel, D. Michiel; Peinado, Hector; Perut, Francesca; Pfaffl, Michael W.; Phinney, Donald G.; Pieters, Bartijn C. H.; Pink, Ryan C.; Pisetsky, David S.; von Strandmann, Elke Pogge; Polakovicova, Iva; Poon, Ivan K. H.; Powell, Bonita H.; Prada, Ilaria; Pulliam, Lynn; Quesenberry, Peter; Radeghieri, Annalisa; Raffai, Robert L.; Raimondo, Stefania; Rak, Janusz; Ramirez, Marcel; Raposo, Graca; Rayyan, Morsi S.; Regev-Rudzki, Neta; Ricklefs, Franz L.; Robbins, Paul D.; Roberts, David D.; Rodrigues, Silvia C.; Rohde, Eva; Rome, Sophie; Rouschop, Kasper M. A.; Rughetti, Aurelia; Russell, Ashley E.; Saa, Paula; Sahoo, Susmita; Salas-Huenuleo, Edison; Sanchez, Catherine; Saugstad, Julie A.; Saul, Meike J.; Schiffelers, Raymond M.; Schneider, Raphael; Schoyen, Tine Hiorth; Scott, Aaron; Shahaj, Eriomina; Sharma, Shivani; Shatnyeva, Olga; Shekari, Faezeh; Shelke, Ganesh Vilas; Shetty, Ashok K.; Shiba, Kiyotaka; Siljander, Pia R-M; Silva, Andreia M.; Skowronek, Agata; Snyder, Orman L.; Soares, Rodrigo Pedro; Sodar, Barbara W.; Soekmadji, Carolina; Sotillo, Javier; Stahl, Philip D.; Stoorvogel, Willem; Stott, Shannon L.; Strasser, Erwin F.; Swift, Simon; Tahara, Hidetoshi; Tewari, Muneesh; Timms, Kate; Tiwari, Swasti; Tixeira, Rochelle; Tkach, Mercedes; Toh, Wei Seong; Tomasini, Richard; Torrecilhas, Ana Claudia; Pablo Tosar, Juan; Toxavidis, Vasilis; Urbanelli, Lorena; Vader, Pieter; van Balkom, Bas W. M.; van der Grein, Susanne G.; Van Deun, Jan; van Herwijnen, Martijn J. C.; Van Keuren-Jensen, Kendall; van Niel, Guillaume; van Royen, Martin E.; van Wijnen, Andre J.; Helena Vasconcelos, M.; Vechetti, Ivan J.; Veit, Tiago D.; Vella, Laura J.; Velot, Emilie; Verweij, Frederik J.; Vestad, Beate; Vinas, Jose L.; Visnovitz, Tamas; Vukman, Krisztina V.; Wahlgren, Jessica; Watson, Dionysios C.; Wauben, Marca H. M.; Weaver, Alissa; Webber, Jason P.; Weber, Viktoria; Wehman, Ann M.; Weiss, Daniel J.; Welsh, Joshua A.; Wendt, Sebastian; Wheelock, Asa M.; Wiener, Zoltan; Witte, Leonie; Wolfram, Joy; Xagorari, Angeliki; Xander, Patricia; Xu, Jing; Yan, Xiaomei; Yanez-Mo, Maria; Yin, Hang; Yuana, Yuana; Zappulli, Valentina; Zarubova, Jana; Zekas, Vytautas; Zhang, Jian-ye; Zhao, Zezhou; Zheng, Lei; Zheutlin, Alexander R.; Zickler, Antje M.; Zimmermann, Pascale; Zivkovic, Angela M.; Zocco, Davide; Zuba-Surma, Ewa K.
Contributor: University of Helsinki, University of Hamburg
University of Helsinki, University of Nebraska, Medical Center
University of Helsinki, Extracellular Vesicles
Date: 2018-11-23
Language: eng
Number of pages: 43
Belongs to series: Journal of Extracellular Vesicles
ISSN: 2001-3078
URI: http://hdl.handle.net/10138/278414
Abstract: The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
Subject: extracellular vesicles
exosomes
ectosomes
microvesicles
minimal information requirements
guidelines
standardization
microparticles
rigor
reproducibility
CELL-DERIVED MICROPARTICLES
SURFACE-PLASMON RESONANCE
SIZE-EXCLUSION CHROMATOGRAPHY
FIELD-FLOW FRACTIONATION
HUMAN URINARY EXOSOMES
PROSTATE-CANCER
MEMBRANE-VESICLES
FETAL BOVINE
CIRCULATING MICROPARTICLES
PREANALYTICAL PARAMETERS
1182 Biochemistry, cell and molecular biology
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