Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers

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Määttä , O L M , Laurila , H P , Holopainen , S , Lilja-Maula , L , Melamies , M , Viitanen , S J , Johnson , L R , Koho , N , Neuvonen , M , Niemi , M & Rajamäki , M M 2018 , ' Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers ' , Journal of Veterinary Internal Medicine , vol. 32 , no. 6 , pp. 2074-2081 . https://doi.org/10.1111/jvim.15321

Title: Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers
Author: Määttä, O. L. M.; Laurila, H. P.; Holopainen, S.; Lilja-Maula, L.; Melamies, M.; Viitanen, S. J.; Johnson, L. R.; Koho, N.; Neuvonen, M.; Niemi, M.; Rajamäki, M. M.
Contributor: University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Equine and Small Animal Medicine
University of Helsinki, Department of Clinical Pharmacology
University of Helsinki, Department of Clinical Pharmacology
University of Helsinki, Minna Marjaana Rajamäki / Principal Investigator
Date: 2018-11
Language: eng
Number of pages: 8
Belongs to series: Journal of Veterinary Internal Medicine
ISSN: 0891-6640
URI: http://hdl.handle.net/10138/286190
Abstract: Background: Gastroesophageal reflux and microaspiration (MA) of gastric juice are associated with various human respiratory diseases but not in dogs. Objective: To detect the presence of bile acids in bronchoalveolar lavage fluid (BALF) of dogs with various respiratory diseases. Animals: Twenty-seven West Highland White Terriers (WHWTs) with canine idiopathic pulmonary fibrosis (CIPF), 11 dogs with bacterial pneumonia (BP), 13 with chronic bronchitis (CB), 9 with eosinophilic bronchopneumopathy (EBP), 19 with laryngeal dysfunction (LD), 8 Irish Wolfhounds (IWHs) with previous BPs, 13 healthy WHWTs, all privately owned dogs, and 6 healthy research colony Beagles Methods: Prospective cross-sectional observational study with convenience sampling of dogs. Bile acids were measured by mass spectrometry in BALF samples. Total bile acid (TBA) concentration was calculated as a sum of 17 different bile acids. Results: Concentrations of TBA were above the limit of quantification in 78% of CIPF, 45% of BP, 62% of CB, 44% of EBP, 68% of LD, and 13% of IWH dogs. In healthy dogs, bile acids were detected less commonly in Beagles (0/6) than in healthy WHWTs (10/13). Concentrations of TBA were significantly higher in CIPF (median 0.013 mu M, range not quantifiable [n.q.]-0.14 mu M, P <.001), healthy WHWTs (0.0052 mu M, n.q.-1.2 mu M, P = .003), LD (0.010 mu M, n.q.-2.3 mu M, P = .015), and CB (0.0078 mu M, n.q.-0.073 mu M, P = .018) groups compared to Beagles (0 mu M, n.q.). Conclusion and Clinical Importance: These results suggest that MA occurs in various respiratory diseases of dogs and also in healthy WHWTs.
Subject: bile acid
bronchoalveolar lavage fluid
canine
microaspiration
IDIOPATHIC PULMONARY-FIBROSIS
GASTROESOPHAGEAL-REFLUX
ACUTE EXACERBATION
PNEUMONIA
PEPSIN
MICROASPIRATION
SYMPTOMS
413 Veterinary science
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