Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers

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Määttä , O L M , Laurila , H P , Holopainen , S , Lilja-Maula , L , Melamies , M , Viitanen , S J , Johnson , L R , Koho , N , Neuvonen , M , Niemi , M & Rajamäki , M M 2018 , ' Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers ' , Journal of Veterinary Internal Medicine , vol. 32 , no. 6 , pp. 2074-2081 . https://doi.org/10.1111/jvim.15321

Title: Reflux aspiration in lungs of dogs with respiratory disease and in healthy West Highland White Terriers
Author: Määttä, O. L. M.; Laurila, H. P.; Holopainen, S.; Lilja-Maula, L.; Melamies, M.; Viitanen, S. J.; Johnson, L. R.; Koho, N.; Neuvonen, M.; Niemi, M.; Rajamäki, M. M.
Contributor organization: Equine and Small Animal Medicine
Veterinary Teaching Hospital
Department of Clinical Pharmacology
Minna Marjaana Rajamäki / Principal Investigator
Date: 2018-11
Language: eng
Number of pages: 8
Belongs to series: Journal of Veterinary Internal Medicine
ISSN: 0891-6640
DOI: https://doi.org/10.1111/jvim.15321
URI: http://hdl.handle.net/10138/286190
Abstract: Background: Gastroesophageal reflux and microaspiration (MA) of gastric juice are associated with various human respiratory diseases but not in dogs. Objective: To detect the presence of bile acids in bronchoalveolar lavage fluid (BALF) of dogs with various respiratory diseases. Animals: Twenty-seven West Highland White Terriers (WHWTs) with canine idiopathic pulmonary fibrosis (CIPF), 11 dogs with bacterial pneumonia (BP), 13 with chronic bronchitis (CB), 9 with eosinophilic bronchopneumopathy (EBP), 19 with laryngeal dysfunction (LD), 8 Irish Wolfhounds (IWHs) with previous BPs, 13 healthy WHWTs, all privately owned dogs, and 6 healthy research colony Beagles Methods: Prospective cross-sectional observational study with convenience sampling of dogs. Bile acids were measured by mass spectrometry in BALF samples. Total bile acid (TBA) concentration was calculated as a sum of 17 different bile acids. Results: Concentrations of TBA were above the limit of quantification in 78% of CIPF, 45% of BP, 62% of CB, 44% of EBP, 68% of LD, and 13% of IWH dogs. In healthy dogs, bile acids were detected less commonly in Beagles (0/6) than in healthy WHWTs (10/13). Concentrations of TBA were significantly higher in CIPF (median 0.013 mu M, range not quantifiable [n.q.]-0.14 mu M, P <.001), healthy WHWTs (0.0052 mu M, n.q.-1.2 mu M, P = .003), LD (0.010 mu M, n.q.-2.3 mu M, P = .015), and CB (0.0078 mu M, n.q.-0.073 mu M, P = .018) groups compared to Beagles (0 mu M, n.q.). Conclusion and Clinical Importance: These results suggest that MA occurs in various respiratory diseases of dogs and also in healthy WHWTs.
Subject: bile acid
bronchoalveolar lavage fluid
canine
microaspiration
IDIOPATHIC PULMONARY-FIBROSIS
GASTROESOPHAGEAL-REFLUX
ACUTE EXACERBATION
PNEUMONIA
PEPSIN
MICROASPIRATION
SYMPTOMS
413 Veterinary science
Peer reviewed: Yes
Rights: cc_by_nc
Usage restriction: openAccess
Self-archived version: draft


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