Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation

Show full item record



Permalink

http://hdl.handle.net/10138/287695

Citation

Draper , L A , Ryan , F J , Smith , M K , Jalanka , J , Mattila , E , Arkkila , P , Ross , R P , Satokari , R & Hill , C 2018 , ' Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation ' , Microbiome , vol. 6 , 220 . https://doi.org/10.1186/s40168-018-0598-x

Title: Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation
Author: Draper, L. A.; Ryan, F. J.; Smith, M. K.; Jalanka, J.; Mattila, E.; Arkkila, P.; Ross, R. P.; Satokari, R.; Hill, C.
Contributor: University of Helsinki, Immunobiology Research Program
University of Helsinki, Infektiosairauksien yksikkö
University of Helsinki, Department of Medicine
University of Helsinki, Reetta Maria Satokari / Principal Investigator
Date: 2018-12-10
Language: eng
Number of pages: 9
Belongs to series: Microbiome
ISSN: 2049-2618
URI: http://hdl.handle.net/10138/287695
Abstract: BackgroundFaecal microbiota transplantation (FMT) is used in the treatment of recurrent Clostridium difficile infection. Its success is typically attributed to the restoration of a diverse microbiota. Viruses (including bacteriophages) are the most numerically dominant and potentially the most diverse members of the microbiota, but their fate following FMT has not been well studied.ResultsWe studied viral transfer following FMT from 3 donors to 14 patients. Recipient viromes resembled those of their donors for up to 12months. Tracking individual bacteriophage colonisation revealed that engraftment of individual bacteriophages was dependent on specific donor-recipient pairings. Specifically, multiple recipients from a single donor displayed highly individualised virus colonisation patterns.ConclusionsThe impact of viruses on long-term microbial dynamics is a factor that should be reviewed when considering FMT as a therapeutic option.
Subject: Faecal microbiota transplantation
Bacteriophages
Viruses
Engraftment
Persistence
Donor-recipient
CLOSTRIDIUM-DIFFICILE INFECTION
HUMAN GUT VIROME
READ ALIGNMENT
3111 Biomedicine
1183 Plant biology, microbiology, virology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s40168_018_0598_x.pdf 965.1Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record