A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes

Show full item record



Permalink

http://hdl.handle.net/10138/288720

Citation

SUMMIT Consortium 2018 , ' A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes ' , PLoS One , vol. 13 , no. 12 , 0208654 . https://doi.org/10.1371/journal.pone.0208654

Title: A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes
Author: SUMMIT Consortium
Date: 2018-12-19
Language: eng
Number of pages: 13
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/288720
Abstract: To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p <1.0 x 10(-4)) in an independent case-control study (Stage-2; 1,213 cases and 1,298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 x 10(-10). We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1,221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 x 10(-10)). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.
Subject: GENOME-WIDE ASSOCIATION
RENAL-DISEASE
OBESITY
GENE
COMPLICATIONS
POLYMORPHISM
MELLITUS
3111 Biomedicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
journal.pone.0208654.pdf 1.002Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record