Activation of the motivation-related ventral striatum during delusional experience

Show full item record



Permalink

http://hdl.handle.net/10138/292424

Citation

Raij , T T , Riekki , T J J , Rikandi , E , Mäntylä , T , Kieseppä , T & Suvisaari , J 2018 , ' Activation of the motivation-related ventral striatum during delusional experience ' , Translational Psychiatry , vol. 8 , 283 . https://doi.org/10.1038/s41398-018-0347-8

Title: Activation of the motivation-related ventral striatum during delusional experience
Author: Raij, Tuukka T.; Riekki, Tapani J. J.; Rikandi, Eva; Mäntylä, Teemu; Kieseppä, Tuula; Suvisaari, Jaana
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, National Institute for Health and Welfare (THL)
Date: 2018-12-18
Language: eng
Number of pages: 8
Belongs to series: Translational Psychiatry
ISSN: 2158-3188
URI: http://hdl.handle.net/10138/292424
Abstract: Delusion is the most characteristic symptom of psychosis, occurring in almost all first-episode psychosis patients. The motivational salience hypothesis suggests delusion to originate from the experience of abnormal motivational salience. Whether the motivation-related brain circuitries are activated during the actual delusional experience remains, however, unknown. We used a forced-choice answering tree at random intervals during functional magnetic resonance imaging to capture delusional and non-delusional spontaneous experiences in patients with first-episode psychosis (n = 31) or clinical high-risk state (n = 7). The motivation-related brain regions were identified by an automated meta-analysis of 149 studies. Thirteen first-episode patients reported both delusional and non-delusional spontaneous experiences. In these patients, delusional experiences were related to stronger activation of the ventral striatum in both hemispheres. This activation overlapped with the most strongly motivation-related brain regions. These findings provide an empirical link between the actual delusional experience and the motivational salience hypothesis. Further use and development of the present methods in localizing the neurobiological basis of the most characteristic symptoms may be useful in the search for etiopathogenic pathways that result in psychotic disorders.
Subject: PERSECUTORY DELUSIONS
ABERRANT SALIENCE
COGNITIVE STATES
SCHIZOPHRENIA
PSYCHOSIS
DOPAMINE
NETWORK
SYMPTOMS
HALLUCINATIONS
PHENOMENOLOGY
3124 Neurology and psychiatry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41398_018_0347_8.pdf 525.9Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record