A convenient and efficient synthesis of thiazolidin-4-ones via cyclization of substituted hydrazinecarbothioamides

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Hassan , A A , Mohamed , N K , El-Shaieb , K M A , Tawfeek , H N , Bräse , S & Nieger , M 2019 , ' A convenient and efficient synthesis of thiazolidin-4-ones via cyclization of substituted hydrazinecarbothioamides ' , Arabian journal of chemistry , vol. 12 , no. 2 , pp. 289-294 . https://doi.org/10.1016/j.arabjc.2014.10.035

Title: A convenient and efficient synthesis of thiazolidin-4-ones via cyclization of substituted hydrazinecarbothioamides
Author: Hassan, Alaa A.; Mohamed, Nasr K.; El-Shaieb, Kamal M. A.; Tawfeek, Hendawy N.; Bräse, Stefan; Nieger, Martin
Contributor: University of Helsinki, Department of Chemistry
Date: 2019-02
Language: eng
Number of pages: 6
Belongs to series: Arabian journal of chemistry
ISSN: 1878-5352
URI: http://hdl.handle.net/10138/298897
Abstract: 2-Substituted hydrazinecarbothioamides and N ,2-disubstituted hydrazinecarbothioamides react in high yield with dimethyl acetylenedicarboxylate (DMAD) to give 4-oxo-Z-(thiazolidin-5-ylidene) acetate derivatives. Several mechanistic options involving interaction are presented. The structures of thiazolidin-4-ones have been unambiguously confirmed by single crystal X-ray crystallography. (C) 2014 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
Subject: Hydrazinecarbothioamides
Dimethyl acetylenedicarboxylate
Thiazolidin-4-ones
X-ray crystallography
BIOLOGICAL EVALUATION
DERIVATIVES
FACILE
THIAZOLES
DESIGN
POTENT
116 Chemical sciences
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