A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations

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Hebbar , P , Abubaker , J A , Abu-Farha , M , Tuomilehto , J , Al-Mulla , F & Thanaraj , T A 2019 , ' A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations ' , Frontiers in Endocrinology , vol. 10 , 8 . https://doi.org/10.3389/fendo.2019.00008

Title: A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations
Author: Hebbar, Prashantha; Abubaker, Jehad Ahmed; Abu-Farha, Mohamed; Tuomilehto, Jaakko; Al-Mulla, Fahd; Thanaraj, Thangavel Alphonse
Contributor: University of Helsinki, Public Health
Belongs to series: Frontiers in Endocrinology
ISSN: 1664-2392
Abstract: Despite dedicated nation-wide efforts to raise awareness against the harmful effects of fast-food consumption and sedentary lifestyle, the Arab population continues to struggle with an increased risk for metabolic disorders. Unlike the European population, the Arab population lacks well-established genetic risk determinants for metabolic disorders, and the transferability of established risk loci to this population has not been satisfactorily demonstrated. The most recent findings have identified over 240 genetic risk loci (with similar to 400 independent association signals) for type 2 diabetes, but thus far only 25 risk loci (ADAMTS9, ALX4, BCL11A, CDKAL1, CDKN2A/B, COL8A1, DUSP9, FTO, GCK, GNPDA2, HMG20A, HNF1A, HNF1B, HNF4A, IGF2BP2, JAZF1, KCNJ11 , KCNQ1, MC4R, PPAR gamma, SLC30A8, TCF7L2, TFAP2B, TP53INP1, and WFS1) have been replicated in Arab populations. To our knowledge, large-scale population- or family-based association studies are non-existent in this region. Recently, we conducted genome-wide association studies on Arab individuals from Kuwait to delineate the genetic determinants for quantitative traits associated with anthropometry, lipid profile, insulin resistance, and blood pressure levels. Although these studies led to the identification of novel recessive variants, they failed to reproduce the established loci. However, they provided insights into the genetic architecture of the population, the applicability of genetic models based on recessive mode of inheritance, the presence of genetic signatures of inbreeding due to the practice of consanguinity, and the pleiotropic effects of rare disorders on complex metabolic disorders. This perspective presents analysis strategies and study designs for identifying genetic risk variants associated with diabetes and related traits in Arab populations.
URI: http://hdl.handle.net/10138/298920
Date: 2019-01-28
Subject: Arab population
type 2 diabetes
genome-wide association studies
risk loci
Kuwait
Euro-centric risk variants
genetics
epigenetics
TYPE-2 DIABETES-MELLITUS
COMORBID CHRONIC CONDITIONS
BODY-MASS INDEX
MISSING HERITABILITY
SUSCEPTIBILITY LOCI
DNA METHYLATION
COMMON VARIANTS
SAMPLE-SIZE
ASSOCIATION
RISK
3121 Internal medicine
3142 Public health care science, environmental and occupational health
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