A minitablet formulation made from electrospun nanofibers

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Poller , B , Strachan , C , Broadbent , R & Walker , G F 2017 , ' A minitablet formulation made from electrospun nanofibers ' , European Journal of Pharmaceutics and Biopharmaceutics , vol. 114 , pp. 213-220 . https://doi.org/10.1016/j.ejpb.2017.01.022

Title: A minitablet formulation made from electrospun nanofibers
Author: Poller, Bettina; Strachan, Clare; Broadbent, Roland; Walker, Greg F.
Contributor: University of Helsinki, Faculty of Pharmacy
Date: 2017-05
Language: eng
Number of pages: 8
Belongs to series: European Journal of Pharmaceutics and Biopharmaceutics
ISSN: 0939-6411
URI: http://hdl.handle.net/10138/299389
Abstract: The purpose of this study was to evaluate electrospun drug loaded nanofibers as a new matrix for mini tablets. Prednisone, a poorly water-soluble drug, was loaded into povidone (polyvinylpyrrolidone, PVP) nanofibers using the process of electrospinning. The drug-loaded nanofiber mat was compressed into minitablets with a 2 mm diameter and a height of 2.63 0.04 mm. SEM analysis of the minitablet identified a nano-web structure with a nanofiber diameter in the range of 400-500 nm. The minitablets met the requirements of the US Pharmacopeia with respect to content uniformity and friability. DSC and XRPD analysis of the minitablet indicated that the drug-polymer mixture was a one-phase amorphous system. XRPD analysis of the drug loaded nanofiber mat after 10-months of storage at ambient temperature showed no evidence of recrystallization of the drug. Solubility and dissolution properties of the drug formulated into a nanofiber mat and minitablet were evaluated. These results show that electrospun nanofibers may provide a useful matrix for the further development of minitablets. (C) 2017 Elsevier B.V. All rights reserved.
Subject: POLYVINYLPYRROLIDONE FIBER MATS
WATER-SOLUBLE DRUGS
MINI-TABLETS
DOSAGE FORMS
DELIVERY
INDOMETHACIN
DISPERSIONS
CHILDREN
STATE
DISSOLUTION
317 Pharmacy
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