Orexins, Sleep, and Blood Pressure

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Sieminski , M , Szypenbejl , J & Partinen , E 2018 , ' Orexins, Sleep, and Blood Pressure ' , Current Hypertension Reports , vol. 20 , no. 9 , 79 . https://doi.org/10.1007/s11906-018-0879-6

Title: Orexins, Sleep, and Blood Pressure
Author: Sieminski, Mariusz; Szypenbejl, Jacek; Partinen, Eemil
Other contributor: University of Helsinki, Clinicum
Date: 2018-09
Language: eng
Number of pages: 8
Belongs to series: Current Hypertension Reports
ISSN: 1522-6417
DOI: https://doi.org/10.1007/s11906-018-0879-6
URI: http://hdl.handle.net/10138/299402
Abstract: The aim of this review was to summarize collected data on the role of orexin and orexin neurons in the control of sleep and blood pressure. Although orexins (hypocretins) have been known for only 20 years, an impressive amount of data is now available regarding their physiological role. Hypothalamic orexin neurons are responsible for the control of food intake and energy expenditure, motivation, circadian rhythm of sleep and wake, memory, cognitive functions, and the cardiovascular system. Multiple studies show that orexinergic stimulation results in increased blood pressure and heart rate and that this effect may be efficiently attenuated by orexinergic antagonism. Increased activity of orexinergic neurons is also observed in animal models of hypertension. Pharmacological intervention in the orexinergic system is now one of the therapeutic possibilities in insomnia. Although the role of orexin in the control of blood pressure is well described, we are still lacking clinical evidence that this is a possibility for a new approach in the treatment of cardiovascular diseases.
Subject: Orexin
Hypocretin
Blood pressure
Sleep
Narcolepsy
Autonomic nervous system
SPONTANEOUSLY HYPERTENSIVE-RATS
ROSTRAL VENTROLATERAL MEDULLA
SOMATO-SYMPATHETIC REFLEX
PLACEBO-CONTROLLED TRIAL
RECEPTOR ANTAGONIST
NARCOLEPTIC PATIENTS
HYPOCRETIN OREXIN
PHYSICAL-ACTIVITY
PREPRO-OREXIN
FOOD-INTAKE
3124 Neurology and psychiatry
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