Aggressive behaviour in childhood and adolescence : the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium

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Malanchini , M , Smith-Woolley , E , Ayorech , Z , Rimfeld , K , Krapohl , E , Vuoksimaa , E , Korhonen , T , Bartels , M , van Beijsterveldt , T C E M , Rose , R J , Lundstrom , S , Anckarsater , H , Kaprio , J , Lichtenstein , P , Boomsma , D I & Plomin , R 2019 , ' Aggressive behaviour in childhood and adolescence : the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium ' , Psychological Medicine , vol. 49 , no. 4 , pp. 646-654 . https://doi.org/10.1017/S0033291718001344

Title: Aggressive behaviour in childhood and adolescence : the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium
Author: Malanchini, Margherita; Smith-Woolley, Emily; Ayorech, Ziada; Rimfeld, Kaili; Krapohl, Eva; Vuoksimaa, Eero; Korhonen, Tellervo; Bartels, Meike; van Beijsterveldt, Toos C. E. M.; Rose, Richard J.; Lundstrom, Sebastian; Anckarsater, Henrik; Kaprio, Jaakko; Lichtenstein, Paul; Boomsma, Dorret I.; Plomin, Robert
Other contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland




Date: 2019-03
Language: eng
Number of pages: 9
Belongs to series: Psychological Medicine
ISSN: 0033-2917
DOI: https://doi.org/10.1017/S0033291718001344
URI: http://hdl.handle.net/10138/299789
Abstract: Background Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence. Methods Data came from four prospective twin cohorts - Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study - who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9-10; 12; 14-15 and 16-18. Results MSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4% (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1% of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression. Conclusions Perinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents' aggressive behaviour.
Subject: Adolescence
aggression
cross-cultural
maternal smoking during pregnancy
meta-analysis
parental aggression
paternal smoking
perinatal
MATERNAL CIGARETTE-SMOKING
SUBSTANCE USE
EXPOSURE
RISK
ASSOCIATION
FAMILY
PREDICTORS
SYMPTOMS
DISORDER
CHILDREN
3124 Neurology and psychiatry
515 Psychology
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