Age at first birth in women is genetically associated with increased risk of schizophrenia

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Schizophrenia Working Group of the Psychiatric Genomics Consortium , Ni , G , Gratten , J , Wray , N R , Lee , S H , Eriksson , J G , Paunio , T M , Pietiläinen , O K & Palotie , A V 2018 , ' Age at first birth in women is genetically associated with increased risk of schizophrenia ' , Scientific Reports , vol. 8 , 10168 . https://doi.org/10.1038/s41598-018-28160-z

Title: Age at first birth in women is genetically associated with increased risk of schizophrenia
Author: Schizophrenia Working Group of the Psychiatric Genomics Consortium; Ni, Guiyan; Gratten, Jacob; Wray, Naomi R.; Lee, Sang Hong; Eriksson, Johan Gunnar; Paunio, Tiina Maria; Pietiläinen, Olli Kalevi; Palotie, Aarno Veikko
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, University Management
University of Helsinki, Center for Population, Health and Society
University of Helsinki, Centre of Excellence in Complex Disease Genetics
Date: 2018-07-05
Language: eng
Number of pages: 14
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/300059
Abstract: Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.
Subject: 3124 Neurology and psychiatry
DE-NOVO MUTATIONS
PATERNAL-AGE
PSYCHIATRIC-DISORDERS
BIPOLAR DISORDER
SCORE REGRESSION
COMMON SNPS
PROPORTION
TRAITS
CHILD
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