A molecular atlas of cell types and zonation in the brain vasculature

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http://hdl.handle.net/10138/301079

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Vanlandewijck , M , He , L , Mäe , M A A , Andrae , J , Ando , K , Del Gaudio , F , Nahar , K , Lebouvier , T , Lavina , B , Gouveia , L , Sun , Y , Raschperger , E , Räsänen , M , Zarb , Y , Mochizuki , N , Keller , A , Lendahl , U & Betsholtz , C 2018 , ' A molecular atlas of cell types and zonation in the brain vasculature ' , Nature , vol. 554 , no. 7693 , pp. 475-+ . https://doi.org/10.1038/nature25739

Title: A molecular atlas of cell types and zonation in the brain vasculature
Author: Vanlandewijck, Michael; He, Liqun; Mäe, Maarj A. Andaloussi; Andrae, Johanna; Ando, Koji; Del Gaudio, Francesca; Nahar, Khayrun; Lebouvier, Thibaud; Lavina, Barbara; Gouveia, Leonor; Sun, Ying; Raschperger, Elisabeth; Räsänen, Markus; Zarb, Yvette; Mochizuki, Naoki; Keller, Annika; Lendahl, Urban; Betsholtz, Christer
Contributor: University of Helsinki, Translational Cancer Biology (TCB) Research Programme
Date: 2018-02-22
Language: eng
Number of pages: 34
Belongs to series: Nature
ISSN: 0028-0836
URI: http://hdl.handle.net/10138/301079
Abstract: Cerebrovascular disease is the third most common cause of death in developed countries, but our understanding of the cells that compose the cerebral vasculature is limited. Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular and vessel-associated cells in the adult mouse brain. We uncover the transcriptional basis of the gradual phenotypic change (zonation) along the arteriovenous axis and reveal unexpected cell type differences: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells. We also provide insight into pericyte organotypicity and define a population of perivascular fibroblast-like cells that are present on all vessel types except capillaries. Our work illustrates the power of single-cell transcriptomics to decode the higher organizational principles of a tissue and may provide the initial chapter in a molecular encyclopaedia of the mammalian vasculature.
Subject: CENTRAL-NERVOUS-SYSTEM
MESENCHYMAL STEM-CELLS
BMX TYROSINE KINASE
ENDOTHELIAL-CELLS
GENE-EXPRESSION
RNA-SEQ
CAPILLARY PERICYTES
BARRIER TRANSPORT
BETA-PEPTIDE
SINGLE CELLS
3111 Biomedicine
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