Active Matrix Metalloproteinase-8 Point-of-Care (PoC)/Chairside Mouthrinse Test vs. Bleeding on Probing in Diagnosing Subclinical Periodontitis in Adolescents

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Räisänen , I T , Sorsa , T , van der Schoor , G-J , Tervahartiala , T , van der Schoor , P , Gieselmann , D-R & Heikkinen , A M 2019 , ' Active Matrix Metalloproteinase-8 Point-of-Care (PoC)/Chairside Mouthrinse Test vs. Bleeding on Probing in Diagnosing Subclinical Periodontitis in Adolescents ' , Diagnostics , vol. 9 , no. 1 , 34 . https://doi.org/10.3390/diagnostics9010034

Title: Active Matrix Metalloproteinase-8 Point-of-Care (PoC)/Chairside Mouthrinse Test vs. Bleeding on Probing in Diagnosing Subclinical Periodontitis in Adolescents
Author: Räisänen, Ismo T.; Sorsa, Timo; van der Schoor, Gerrit-Jan; Tervahartiala, Taina; van der Schoor, Peter; Gieselmann, Dirk-Rolf; Heikkinen, Anna Maria
Contributor: University of Helsinki, University of Helsinki
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Clinicum
University of Helsinki, Department of Oral and Maxillofacial Diseases
Date: 2019-03-23
Language: eng
Number of pages: 9
Belongs to series: Diagnostics
ISSN: 2075-4418
URI: http://hdl.handle.net/10138/301417
Abstract: This cross-sectional study compares the effectiveness of an active MMP-8 (aMMP-8) point-of-care (PoC)/chairside mouthrinse test to the conventional bleeding on probing (BOP) (cutoff 20%) test in detecting subclinical periodontitis/pre-periodontitis in Finnish adolescents. The study was carried out at the Kotka Health Center, Finland. A total of 47 adolescents (30 boys/17 girls) aged 15-17 were first tested with the aMMP-8 PoC test, followed by a full-mouth evaluation of clinical parameters of oral health including periodontal, oral mucosal, and caries assessment. A periodontist performed these clinical examinations. The aMMP-8 PoC test result had much stronger association with subclinical periodontitis than the BOP 20% test (2.8-5.3 times stronger in terms of odds ratio). The aMMP-8 PoC test had >= 2 times higher sensitivity than the BOP 20% test with, generally, the same specificity. Further, the aMMP-8 PoC test had generally better accuracy and lower false negative percentages. The aMMP-8 PoC test seemed to be more effective than the conventional BOP test in detecting subclinical periodontitis/pre-periodontitis in adolescents reducing the risk of their undertreatment. However, the sample size may be a limiting factor, and more studies are needed to confirm our results for both adolescents and adults.
Subject: adolescent
periodontitis
matrix metalloproteinases
point-of-care testing
gingival bleeding on probing
GINGIVAL CREVICULAR FLUID
NEUTROPHIL COLLAGENASE ACTIVITY
IN-VIVO
DISEASE
MMP-8
MYELOPEROXIDASE
BACTEREMIA
ACTIVATION
SALIVA
313 Dentistry
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