Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

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Kupers , L K , Monnereau , C , Sharp , G C , Yousefi , P , Salas , L A , Ghantous , A , Page , C M , Reese , S E , Wilcox , A J , Czamara , D , Starling , A P , Novoloaca , A , Lent , S , Roy , R , Hoyo , C , Breton , C , Allard , C , Just , A C , Bakulski , K M , Holloway , J W , Everson , T M , Xu , C-J , Huang , R-C , van der Plaat , D A , Wielscher , M , Merid , S K , Ullemar , V , Rezwan , F , Lahti , J , van Dongen , J , Langie , S A S , Richardson , T G , Magnus , M C , Nohr , E A , Xu , Z , Duijts , L , Zhao , S , Zhang , W , Plusquin , M , DeMeo , D L , Solomon , O , Heimovaara , J H , Jima , D D , Gao , L , Bustamante , M , Perron , P , Wright , R O , Hertz-Picciotto , I , Zhang , H , Karagas , M R , Gehring , U , Marsit , C J , Beilin , L J , Vonk , J M , Jarvelin , M-R , Bergstrom , A , Ortqvist , A K , Ewart , S , Villa , P M , Moore , S E , Willemsen , G , Standaert , A R L , Haberg , S E , Sorensen , T I A , Taylor , J A , Räikkönen , K , Yang , I , Kechris , K , Nawrot , T S , Silver , M J , Gong , Y Y , Richiardi , L , Kogevinas , M , Litonjua , A A , Eskenazi , B , Huen , K , Mbarek , H , Maguire , R L , Dwyer , T , Vrijheid , M , Bouchard , L , Baccarelli , A A , Croen , L A , Karmaus , W , Anderson , D , de Vries , M , Sebert , S , Kere , J , Karlsson , R , Arshad , S H , Hämäläinen , E , Routledge , M N , Boomsma , D , Feinberg , A P , Newschaffer , C J , Govarts , E , Moisse , M , Fallin , M D , Melen , E , Prentice , A M , Kajantie , E , Almqvist , C , Oken , E , Dabelea , D , Boezen , H M , Melton , P E , Wright , R J , Koppelman , G H , Trevisi , L , Hivert , M-F , Sunyer , J , Munthe-Kaas , M C , Murphy , S K , Corpeleijn , E , Wiemels , J , Holland , N , Herceg , Z , Binder , E B , Smith , G D , Jaddoe , V W V , Lie , R T , Nystad , W , London , S J , Lawlor , D A , Relton , C L , Snieder , H & Felix , J F 2019 , ' Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight ' , Nature Communications , vol. 10 , 1893 . https://doi.org/10.1038/s41467-019-09671-3

Title: Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Author: Kupers, Leanne K.; Monnereau, Claire; Sharp, Gemma C.; Yousefi, Paul; Salas, Lucas A.; Ghantous, Akram; Page, Christian M.; Reese, Sarah E.; Wilcox, Allen J.; Czamara, Darina; Starling, Anne P.; Novoloaca, Alexei; Lent, Samantha; Roy, Ritu; Hoyo, Cathrine; Breton, Carrie; Allard, Catherine; Just, Allan C.; Bakulski, Kelly M.; Holloway, John W.; Everson, Todd M.; Xu, Cheng-Jian; Huang, Rae-Chi; van der Plaat, Diana A.; Wielscher, Matthias; Merid, Simon Kebede; Ullemar, Vilhelmina; Rezwan, Faisal; Lahti, Jari; van Dongen, Jenny; Langie, Sabine A. S.; Richardson, Tom G.; Magnus, Maria C.; Nohr, Ellen A.; Xu, Zongli; Duijts, Liesbeth; Zhao, Shanshan; Zhang, Weiming; Plusquin, Michelle; DeMeo, Dawn L.; Solomon, Olivia; Heimovaara, Joosje H.; Jima, Dereje D.; Gao, Lu; Bustamante, Mariona; Perron, Patrice; Wright, Robert O.; Hertz-Picciotto, Irva; Zhang, Hongmei; Karagas, Margaret R.; Gehring, Ulrike; Marsit, Carmen J.; Beilin, Lawrence J.; Vonk, Judith M.; Jarvelin, Marjo-Riitta; Bergstrom, Anna; Ortqvist, Anne K.; Ewart, Susan; Villa, Pia M.; Moore, Sophie E.; Willemsen, Gonneke; Standaert, Arnout R. L.; Haberg, Siri E.; Sorensen, Thorkild I. A.; Taylor, Jack A.; Räikkönen, Katri; Yang, Ivana; Kechris, Katerina; Nawrot, Tim S.; Silver, Matt J.; Gong, Yun Yun; Richiardi, Lorenzo; Kogevinas, Manolis; Litonjua, Augusto A.; Eskenazi, Brenda; Huen, Karen; Mbarek, Hamdi; Maguire, Rachel L.; Dwyer, Terence; Vrijheid, Martine; Bouchard, Luigi; Baccarelli, Andrea A.; Croen, Lisa A.; Karmaus, Wilfried; Anderson, Denise; de Vries, Maaike; Sebert, Sylvain; Kere, Juha; Karlsson, Robert; Arshad, Syed Hasan; Hämäläinen, Esa; Routledge, Michael N.; Boomsma, Dorret; Feinberg, Andrew P.; Newschaffer, Craig J.; Govarts, Eva; Moisse, Matthieu; Fallin, M. Daniele; Melen, Erik; Prentice, Andrew M.; Kajantie, Eero; Almqvist, Catarina; Oken, Emily; Dabelea, Dana; Boezen, H. Marike; Melton, Phillip E.; Wright, Rosalind J.; Koppelman, Gerard H.; Trevisi, Letizia; Hivert, Marie-France; Sunyer, Jordi; Munthe-Kaas, Monica C.; Murphy, Susan K.; Corpeleijn, Eva; Wiemels, Joseph; Holland, Nina; Herceg, Zdenko; Binder, Elisabeth B.; Smith, George Davey; Jaddoe, Vincent W. V.; Lie, Rolv T.; Nystad, Wenche; London, Stephanie J.; Lawlor, Debbie A.; Relton, Caroline L.; Snieder, Harold; Felix, Janine F.
Contributor: University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, STEMM - Stem Cells and Metabolism Research Program
University of Helsinki, Medicum
University of Helsinki, Lastentautien yksikkö
Date: 2019-04-23
Language: eng
Number of pages: 11
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/301673
Abstract: Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P-Bonferroni <1.06 x 10(-7)). In additional analyses in 7,278 participants,
Subject: MENDELIAN RANDOMIZATION
MATERNAL SMOKING
FETAL ORIGINS
CORD BLOOD
EPIGENETIC MEDIATION
GENETIC-EVIDENCE
PREGNANCY
PACKAGE
DISEASE
BIOCONDUCTOR
1184 Genetics, developmental biology, physiology
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