Kupers , L K , Monnereau , C , Sharp , G C , Yousefi , P , Salas , L A , Ghantous , A , Page , C M , Reese , S E , Wilcox , A J , Czamara , D , Starling , A P , Novoloaca , A , Lent , S , Roy , R , Hoyo , C , Breton , C , Allard , C , Just , A C , Bakulski , K M , Holloway , J W , Everson , T M , Xu , C-J , Huang , R-C , van der Plaat , D A , Wielscher , M , Merid , S K , Ullemar , V , Rezwan , F , Lahti , J , van Dongen , J , Langie , S A S , Richardson , T G , Magnus , M C , Nohr , E A , Xu , Z , Duijts , L , Zhao , S , Zhang , W , Plusquin , M , DeMeo , D L , Solomon , O , Heimovaara , J H , Jima , D D , Gao , L , Bustamante , M , Perron , P , Wright , R O , Hertz-Picciotto , I , Zhang , H , Karagas , M R , Gehring , U , Marsit , C J , Beilin , L J , Vonk , J M , Jarvelin , M-R , Bergstrom , A , Ortqvist , A K , Ewart , S , Villa , P M , Moore , S E , Willemsen , G , Standaert , A R L , Haberg , S E , Sorensen , T I A , Taylor , J A , Räikkönen , K , Yang , I , Kechris , K , Nawrot , T S , Silver , M J , Gong , Y Y , Richiardi , L , Kogevinas , M , Litonjua , A A , Eskenazi , B , Huen , K , Mbarek , H , Maguire , R L , Dwyer , T , Vrijheid , M , Bouchard , L , Baccarelli , A A , Croen , L A , Karmaus , W , Anderson , D , de Vries , M , Sebert , S , Kere , J , Karlsson , R , Arshad , S H , Hämäläinen , E , Routledge , M N , Boomsma , D , Feinberg , A P , Newschaffer , C J , Govarts , E , Moisse , M , Fallin , M D , Melen , E , Prentice , A M , Kajantie , E , Almqvist , C , Oken , E , Dabelea , D , Boezen , H M , Melton , P E , Wright , R J , Koppelman , G H , Trevisi , L , Hivert , M-F , Sunyer , J , Munthe-Kaas , M C , Murphy , S K , Corpeleijn , E , Wiemels , J , Holland , N , Herceg , Z , Binder , E B , Smith , G D , Jaddoe , V W V , Lie , R T , Nystad , W , London , S J , Lawlor , D A , Relton , C L , Snieder , H & Felix , J F 2019 , ' Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight ' , Nature Communications , vol. 10 , 1893 . https://doi.org/10.1038/s41467-019-09671-3
Title: | Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight |
Author: | Kupers, Leanne K.; Monnereau, Claire; Sharp, Gemma C.; Yousefi, Paul; Salas, Lucas A.; Ghantous, Akram; Page, Christian M.; Reese, Sarah E.; Wilcox, Allen J.; Czamara, Darina; Starling, Anne P.; Novoloaca, Alexei; Lent, Samantha; Roy, Ritu; Hoyo, Cathrine; Breton, Carrie; Allard, Catherine; Just, Allan C.; Bakulski, Kelly M.; Holloway, John W.; Everson, Todd M.; Xu, Cheng-Jian; Huang, Rae-Chi; van der Plaat, Diana A.; Wielscher, Matthias; Merid, Simon Kebede; Ullemar, Vilhelmina; Rezwan, Faisal; Lahti, Jari; van Dongen, Jenny; Langie, Sabine A. S.; Richardson, Tom G.; Magnus, Maria C.; Nohr, Ellen A.; Xu, Zongli; Duijts, Liesbeth; Zhao, Shanshan; Zhang, Weiming; Plusquin, Michelle; DeMeo, Dawn L.; Solomon, Olivia; Heimovaara, Joosje H.; Jima, Dereje D.; Gao, Lu; Bustamante, Mariona; Perron, Patrice; Wright, Robert O.; Hertz-Picciotto, Irva; Zhang, Hongmei; Karagas, Margaret R.; Gehring, Ulrike; Marsit, Carmen J.; Beilin, Lawrence J.; Vonk, Judith M.; Jarvelin, Marjo-Riitta; Bergstrom, Anna; Ortqvist, Anne K.; Ewart, Susan; Villa, Pia M.; Moore, Sophie E.; Willemsen, Gonneke; Standaert, Arnout R. L.; Haberg, Siri E.; Sorensen, Thorkild I. A.; Taylor, Jack A.; Räikkönen, Katri; Yang, Ivana; Kechris, Katerina; Nawrot, Tim S.; Silver, Matt J.; Gong, Yun Yun; Richiardi, Lorenzo; Kogevinas, Manolis; Litonjua, Augusto A.; Eskenazi, Brenda; Huen, Karen; Mbarek, Hamdi; Maguire, Rachel L.; Dwyer, Terence; Vrijheid, Martine; Bouchard, Luigi; Baccarelli, Andrea A.; Croen, Lisa A.; Karmaus, Wilfried; Anderson, Denise; de Vries, Maaike; Sebert, Sylvain; Kere, Juha; Karlsson, Robert; Arshad, Syed Hasan; Hämäläinen, Esa; Routledge, Michael N.; Boomsma, Dorret; Feinberg, Andrew P.; Newschaffer, Craig J.; Govarts, Eva; Moisse, Matthieu; Fallin, M. Daniele; Melen, Erik; Prentice, Andrew M.; Kajantie, Eero; Almqvist, Catarina; Oken, Emily; Dabelea, Dana; Boezen, H. Marike; Melton, Phillip E.; Wright, Rosalind J.; Koppelman, Gerard H.; Trevisi, Letizia; Hivert, Marie-France; Sunyer, Jordi; Munthe-Kaas, Monica C.; Murphy, Susan K.; Corpeleijn, Eva; Wiemels, Joseph; Holland, Nina; Herceg, Zdenko; Binder, Elisabeth B.; Smith, George Davey; Jaddoe, Vincent W. V.; Lie, Rolv T.; Nystad, Wenche; London, Stephanie J.; Lawlor, Debbie A.; Relton, Caroline L.; Snieder, Harold; Felix, Janine F. |
Contributor organization: | Department of Psychology and Logopedics Helsinki Collegium for Advanced Studies Faculty of Medicine University of Helsinki Department of Obstetrics and Gynecology Pregnancy and Genes Clinicum Medicum STEMM - Stem Cells and Metabolism Research Program Juha Kere / Principal Investigator Research Programs Unit HUSLAB Lastentautien yksikkö Children's Hospital HUS Gynecology and Obstetrics HUS Children and Adolescents Developmental Psychology Research Group |
Date: | 2019-04-23 |
Language: | eng |
Number of pages: | 11 |
Belongs to series: | Nature Communications |
ISSN: | 2041-1723 |
DOI: | https://doi.org/10.1038/s41467-019-09671-3 |
URI: | http://hdl.handle.net/10138/301673 |
Abstract: | Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P-Bonferroni <1.06 x 10(-7)). In additional analyses in 7,278 participants, |
Subject: |
MENDELIAN RANDOMIZATION
MATERNAL SMOKING FETAL ORIGINS CORD BLOOD EPIGENETIC MEDIATION GENETIC-EVIDENCE PREGNANCY PACKAGE DISEASE BIOCONDUCTOR 1184 Genetics, developmental biology, physiology |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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