Adverse lipid profile elevates risk for subarachnoid hemorrhage : A prospective population-based cohort study

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Lindbohm , J , Korja , M , Jousilahti , P , Salomaa , V & Kaprio , J 2018 , ' Adverse lipid profile elevates risk for subarachnoid hemorrhage : A prospective population-based cohort study ' , Atherosclerosis , vol. 274 , pp. 112-119 . https://doi.org/10.1016/j.atherosclerosis.2018.05.011

Title: Adverse lipid profile elevates risk for subarachnoid hemorrhage : A prospective population-based cohort study
Author: Lindbohm, Joni; Korja, Miikka; Jousilahti, Pekka; Salomaa, Veikko; Kaprio, Jaakko
Contributor: University of Helsinki, Clinicum
University of Helsinki, Neurokirurgian yksikkö
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2018-07
Language: eng
Number of pages: 8
Belongs to series: Atherosclerosis
ISSN: 0021-9150
URI: http://hdl.handle.net/10138/302451
Abstract: Background and aims: Studies report that both high and low total cholesterol (TC) elevates SAH risk. There are few prospective studies on high-density lipoproteins (HDL-C) and low-density lipoproteins (LDL-C), and apparently none concerns apolipoproteins A and B. We aimed to clarify the association between lipid profile and SAH risk. Methods: The National FINRISK study provided risk-factor data recorded at enrolment between 1972 and 2007. During 1.52 million person-years of follow-up until 2014, 543 individuals suffered from incident hospitalized SAH or outside-hospital-fatal SAH. Cox proportional hazards model was used to calculate the hazard ratios and multiple imputation predicted ApoA1, ApoB, and LDL-C values for cohorts from a time before apolipoprotein-measurement methods were available. Results: One SD elevation (1.28 mmol/l) in TC elevated SAH risk in men (hazard ratio (HR) 1.15 (95% CIs 1.00-1.32)). Low HDL-C levels increased SAH risk, as each SD decrease (0.37 mmol/l) in HDL-C raised the risk in women (HR 1.29 (95% CIs 1.07-1.55)) and men (HR 1.20 (95% CIs 1.14-1.27)). Each SD increase (0.29 g/l) in ApoA1 decreased SAH risk in women (HR 0.85 (95% CIs 0.74-0.97)) and men (HR 0.88 (95% CIs 0.76-1.02)). LDL-C (SD 1.07 mmol/l) and ApoB (SD 0.28 g/l) elevated SAH risk in men with HR 1.15 (95% CIs 1.01-1.31) and HR 1.26 (95% CIs 1.10-1.44) per one SD increase. Age did not change these findings. Conclusions: An adverse lipid profile seems to elevate SAH risk similar to its effect in other cardiovascular diseases, especially in men. Whether SAH incidence diminishes with increasing statin use remains to be studied. (C) 2018 Elsevier B.V. All rights reserved.
Subject: Subarachnoid hemorrhage
Lipid profile
Epidemiology
Risk factors
Missing data
DENSITY-LIPOPROTEIN CHOLESTEROL
SACCULAR INTRACRANIAL ANEURYSM
HOSPITAL DISCHARGE REGISTER
CARDIOVASCULAR RISK
MYOCARDIAL-INFARCTION
SERUM-LIPIDS
STROKE
FINLAND
RUPTURE
DISEASE
3121 General medicine, internal medicine and other clinical medicine
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