MMP-7 expression may influence the rate of distant recurrences and disease-specific survival in HPV-positive oropharyngeal squamous cell carcinoma

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Vento , S I , Jouhi , L , Mohamed , H , Haglund , C , Mäkitie , A A , Atula , T , Hagström , J & Mäkinen , L K 2018 , ' MMP-7 expression may influence the rate of distant recurrences and disease-specific survival in HPV-positive oropharyngeal squamous cell carcinoma ' , Virchows Archiv , vol. 472 , no. 6 , pp. 975-981 . https://doi.org/10.1007/s00428-018-2365-6

Title: MMP-7 expression may influence the rate of distant recurrences and disease-specific survival in HPV-positive oropharyngeal squamous cell carcinoma
Author: Vento, Seija I.; Jouhi, Lauri; Mohamed, Hesham; Haglund, Caj; Mäkitie, Antti A.; Atula, Timo; Hagström, Jaana; Mäkinen, Laura K.
Contributor organization: Korva-, nenä- ja kurkkutautien klinikka
Clinicum
University of Helsinki
Department of Ophthalmology and Otorhinolaryngology
Department of Pathology
Medicum
Translational Cancer Biology (TCB) Research Programme
Department of Surgery
II kirurgian klinikka
Research Programs Unit
HUS Head and Neck Center
HUS Abdominal Center
HUSLAB
Date: 2018-06
Language: eng
Number of pages: 7
Belongs to series: Virchows Archiv
ISSN: 0945-6317
DOI: https://doi.org/10.1007/s00428-018-2365-6
URI: http://hdl.handle.net/10138/303661
Abstract: The objective of this study was to determine if matrix metalloproteinase-7 (MMP-7) expression is related to human papilloma virus (HPV) status, clinical parameters, and outcome in oropharyngeal squamous cell carcinoma (OPSCC). Tumor tissue specimens from 201 OPSCC patients treated with curative intent were available for immunohistochemistry, and the samples were stained with monoclonal MMP-7 antibody. All the patients were followed up at least 3 years or until death. MMP-7 expression did not differ between HPV-positive and HPV-negative patients. MMP-7 was not prognostic among patients with HPV-negative OPSCC. In the HPV-positive subgroup, patients with moderate, high, or very high MMP-7 expression had significantly worse 5-year disease-specific survival (DSS) (56.6%) than patients with absent, or low MMP-7 expression (77.2%), and MMP-7 expression appeared as a prognostic factor in the multivariate analysis. In addition, among HPV-positive OPSCC with moderate, high, or very high MMP-7 expression, the 5-year distant recurrence-free survival was significantly lower (69.6%) than in those who had low or absent MMP-7 expression (97.5%). Our results suggest that among HPV-positive OPSCC patients, high MMP-7 expression is related to worse 5-year DSS and increased rate of distant recurrences.
Subject: Oropharyngeal cancer
Matrix metalloproteinase-7
MMP-7
HPV
Survival analysis
SQUAMOCOLUMNAR JUNCTION CELLS
HUMAN-PAPILLOMAVIRUS HPV
MATRIX METALLOPROTEINASES
TISSUE INHIBITORS
UNITED-STATES
NECK CANCERS
HEAD
POPULATION
MATRILYSIN
PROGNOSIS
3111 Biomedicine
3122 Cancers
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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