A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity

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http://hdl.handle.net/10138/303738

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Syrjälä , E , Nevalainen , J , Peltonen , J , Takkinen , H-M , Hakola , L , Åkerlund , M , Veijola , R , Ilonen , J , Toppari , J , Knip , M & Virtanen , S M 2019 , ' A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity ' , Scientific Reports , vol. 9 , 7760 . https://doi.org/10.1038/s41598-019-44196-1

Title: A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity
Author: Syrjälä, Essi; Nevalainen, Jaakko; Peltonen, Jaakko; Takkinen, Hanna-Mari; Hakola, Leena; Åkerlund, Mari; Veijola, Riitta; Ilonen, Jorma; Toppari, Jorma; Knip, Mikael; Virtanen, Suvi M.
Contributor: University of Helsinki, Children's Hospital
Date: 2019-05-23
Language: eng
Number of pages: 10
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/303738
Abstract: Several dietary factors have been suspected to play a role in the development of advanced islet autoimmunity (IA) and/or type 1 diabetes (T1D), but the evidence is fragmentary. A prospective population-based cohort of 6081 Finnish newborn infants with HLA-DQB1-conferred susceptibility to T1D was followed up to 15 years of age. Diabetes-associated autoantibodies and diet were assessed at 3-to 12-month intervals. We aimed to study the association between consumption of selected foods and the development of advanced IA longitudinally with Cox regression models (CRM), basic joint models (JM) and joint latent class mixed models (JLCMM). The associations of these foods to T1D risk were also studied to investigate consistency between alternative endpoints. The JM showed a marginal association between meat consumption and advanced IA: the hazard ratio adjusted for selected confounding factors was 1.06 (95% CI: 1.00, 1.12). The JLCMM identified two classes in the consumption trajectories of fish and a marginal protective association for high consumers compared to low consumers: the adjusted hazard ratio was 0.68 (0.44, 1.05). Similar findings were obtained for T1D risk with adjusted hazard ratios of 1.13 (1.02, 1.24) for meat and 0.45 (0.23, 0.86) for fish consumption. Estimates from the CRMs were closer to unity and CIs were narrower compared to the JMs. Findings indicate that intake of meat might be directly and fish inversely associated with the development of advanced IA and T1D, and that disease hazards in longitudinal nutritional epidemiology are more appropriately modeled by joint models than with naive approaches.
Subject: HLA-CONFERRED SUSCEPTIBILITY
BETA-CELL AUTOIMMUNITY
LATENT CLASS MODELS
TO-EVENT DATA
DIETARY FACTORS
YOUNG-CHILDREN
R PACKAGE
TYPE-1
TIME
REGRESSION
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
3143 Nutrition
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