Analysis of shared heritability in common disorders of the brain

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Brainstorm Consortium , Anttila , V , Bulik-Sullivan , B , Finucane , H K , Walters , R K , Bras , J , Duncan , L , Escott-Price , V , Falcone , G J , Gormley , P , Malik , R , Patsopoulos , N A , Ripke , S , Wei , Z , Yu , D , Lee , P H , Turley , P , Grenier-Boley , B , Chouraki , V , Kamatani , Y , Berr , C , Letenneur , L , Hannequin , D , Amouyel , P , Boland , A , Deleuze , J-F , Duron , E , Vardarajan , B N , Reitz , C , Goate , A M , Huentelman , M J , Kamboh , M I , Larson , E B , Rogaeva , E , St George-Hyslop , P , Hakonarson , H , Kukull , W A , Palta , P , Wedenoja , J , Artto , V , Kaunisto , M , Vepsäläinen , S , Kurki , M I , Hämäläinen , E , Kaprio , J , Metspalu , A , Keski-Rahkonen , A , Raevuori , A , Ripatti , S , Lönnqvist , J , Daly , M , Palotie , A & Neale , B M 2018 , ' Analysis of shared heritability in common disorders of the brain ' , Science , vol. 360 , no. 6395 , 8757 , pp. 1313-+ . https://doi.org/10.1126/science.aap8757

Title: Analysis of shared heritability in common disorders of the brain
Author: Brainstorm Consortium; Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, Valentina; Falcone, Guido J.; Gormley, Padhraig; Malik, Rainer; Patsopoulos, Nikolaos A.; Ripke, Stephan; Wei, Zhi; Yu, Dongmei; Lee, Phil H.; Turley, Patrick; Grenier-Boley, Benjamin; Chouraki, Vincent; Kamatani, Yoichiro; Berr, Claudine; Letenneur, Luc; Hannequin, Didier; Amouyel, Philippe; Boland, Anne; Deleuze, Jean-Francois; Duron, Emmanuelle; Vardarajan, Badri N.; Reitz, Christiane; Goate, Alison M.; Huentelman, Matthew J.; Kamboh, M. Ilyas; Larson, Eric B.; Rogaeva, Ekaterina; St George-Hyslop, Peter; Hakonarson, Hakon; Kukull, Walter A.; Palta, Priit; Wedenoja, Juho; Artto, Ville; Kaunisto, Mari; Vepsäläinen, Salli; Kurki, Mitja I.; Hämäläinen, Eija; Kaprio, Jaakko; Metspalu, Andres; Keski-Rahkonen, Anna; Raevuori, Anu; Ripatti, Samuli; Lönnqvist, Jouko; Daly, Mark; Palotie, Aarno; Neale, Benjamin M.
Other contributor: University of Helsinki, Aarno Palotie / Principal Investigator
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
University of Helsinki, Neurologian yksikkö
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Public Health
University of Helsinki, Department of Public Health
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Clinicum
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Institute for Molecular Medicine Finland



















Date: 2018-06-22
Language: eng
Number of pages: 13
Belongs to series: Science
ISSN: 0036-8075
DOI: https://doi.org/10.1126/science.aap8757
URI: http://hdl.handle.net/10138/303879
Abstract: Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
Subject: GENOME-WIDE ASSOCIATION
DEFICIT HYPERACTIVITY DISORDER
MAJOR DEPRESSIVE DISORDER
POPULATION-BASED TWIN
LONG-TERM SURVIVAL
BODY-MASS INDEX
ALZHEIMERS-DISEASE
ANOREXIA-NERVOSA
BIPOLAR DISORDER
GENETIC CORRELATIONS
3124 Neurology and psychiatry
1184 Genetics, developmental biology, physiology
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