Activity of rheumatoid arthritis correlates with oral inflammatory burden

Show full item record



Permalink

http://hdl.handle.net/10138/305117

Citation

Äyräväinen , L , Heikkinen , A M , Kuuliala , A , Ahola , K , Koivuniemi , R , Peltola , J , Suomalainen , A , Moilanen , E , Hämäläinen , M , Laasonen , L , Meurman , J H & Leirisalo-Repo , M 2018 , ' Activity of rheumatoid arthritis correlates with oral inflammatory burden ' , Rheumatology International , vol. 38 , no. 9 , pp. 1661-1669 . https://doi.org/10.1007/s00296-018-4108-z

Title: Activity of rheumatoid arthritis correlates with oral inflammatory burden
Author: Äyräväinen, Leena; Heikkinen, Anna Maria; Kuuliala, Antti; Ahola, Kirsi; Koivuniemi, Riitta; Peltola, Jaakko; Suomalainen, Anni; Moilanen, Eeva; Hämäläinen, Mari; Laasonen, Leena; Meurman, Jukka H.; Leirisalo-Repo, Marjatta
Contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Clinicum
University of Helsinki, Department of Bacteriology and Immunology
University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Clinicum
University of Helsinki, Jaakko Peltola Research Group
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2018-09
Language: eng
Number of pages: 9
Belongs to series: Rheumatology International
ISSN: 0172-8172
URI: http://hdl.handle.net/10138/305117
Abstract: To study oral health in patients with rheumatoid arthritis (RA) with emphasis on disease activity and treatment of RA. In this prospective cohort study 81 RA patients [53 early untreated RA (EURA) and 28 chronic RA (CRA) patients with inadequate response to synthetic disease modifying antirheumatic drugs (DMARDs)], underwent rheumatological [Disease Activity Score (28-joint) DAS28] and dental examinations [Total Dental Index (TDI), Decayed Missing Filled Teeth (DMFT) and Decayed Missing Filled Surfaces (DMFS)]. For controls, 43 volunteers were examined. After the examinations, EURA patients started treatment with synthetic DMARDs, oral and intra-articular glucocorticoids. CRA patients were candidates for biological DMARDs. The patients were re-examined mean 16 months later. Results were analyzed with descriptive statistics and logistic regression. TDI was higher in both RA groups at baseline compared to controls [EURA: 2 (2-3); CRA: 2 (1-3); controls 1 (1-3), p = 0.045]. DMFT [r(s) 0.561 (p = 0.002)] and DMFS [r(s) 0.581 (p = 0.001)] associated with DAS28 at baseline in CRA patients. After follow-up, DAS28 associated positively with DMFT [r(s) 0.384 (p = 0.016)] and DMFS [r(s) 0.334 (p = 0.038)] in EURA patients; as well as in CRA patients DMFT [r (s) 0.672 (p = 0.001)], DMFS [r(s) 0.650 (p = 0.001)]. RA patients already in the early phase of the disease had poorer oral health compared to controls. The caries indices associated with the activity of RA in both patient groups. Oral status may thus contribute to the development and further relate to the activity of RA.
Subject: Arthritis, rheumatoid
Oral health
Antirheumatic agents
RISK-FACTORS
SJOGRENS-SYNDROME
OF-RHEUMATOLOGY
SMOKING
HEALTH
DISEASE
EPIDEMIOLOGY
POPULATION
INFECTIONS
VALIDATION
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
_yr_v_inen2018_ ... OfRheumatoidArthritisC.pdf 761.6Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record