Age-specific HPV type distribution in high-grade cervical disease in screened and unvaccinated women

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http://hdl.handle.net/10138/306343

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Aro , K , Nieminen , P , Louvanto , K , Jakobsson , M , Virtanen , S , Lehtinen , M , Dillner , J & Kalliala , I 2019 , ' Age-specific HPV type distribution in high-grade cervical disease in screened and unvaccinated women ' , Gynecologic Oncology , vol. 154 , no. 2 , pp. 354-359 . https://doi.org/10.1016/j.ygyno.2019.05.024

Title: Age-specific HPV type distribution in high-grade cervical disease in screened and unvaccinated women
Author: Aro, Karoliina; Nieminen, Pekka; Louvanto, Karolina; Jakobsson, Maija; Virtanen, Seppo; Lehtinen, Matti; Dillner, Joakim; Kalliala, Ilkka
Contributor: University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, Clinicum
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, Staff Services
Date: 2019-08
Language: eng
Number of pages: 6
Belongs to series: Gynecologic Oncology
ISSN: 0090-8258
URI: http://hdl.handle.net/10138/306343
Abstract: Background and aim. Age-specific type-distribution of high-risk human papillomavirus (hrHPV) in cervical precancerous lesions is subject to change in the HPV vaccination era. Knowing the pre-vaccination type distribution helps to anticipate changes induced by mass vaccination and optimize screening. Methods. We recruited 1279 women referred to colposcopy for abnormal cytology into a population-based study on HPV type distribution in diagnostic cervical samples (ISRCTN10933736). The HPV genotyping findings were grouped as: HPV16/18+, other hrHPV+ (HPV31/33/35/39/45/51/52/56/58/59/66/68), non-vaccine targeted hrHPV+ (HPV35/39/51/56/59/66/68), low-risk HPV, and HPV negative. We estimated the HPV group-specific prevalence rates according to diagnostic histopathological findings in the age groups of = 45 (n = 326). Results. Altogether 503 cases with high grade squamous intraepithelial lesion or worse (HSIL+) were diagnosed. More than half, 285 (56.7%) of HSIL+ cases were associated with HPV16/18: 64.3% (101/157) in women = 45 years of age (RR 0.55, 95% CI 039-0.75). Conversely, other hrHPV's were associated with 191 (38.0%) of HSIL+: 31.9% (50/157) in women = 45 (RR 1.71, 95% CI 126-2.33). The proportion of non-vaccine targeted hrHPV and HPV negative HSIL+ increased with advancing age. Conclusions. Pre-vaccination HPV type distribution in HSIL+ was distinctly polarised by age with HPV16/18 attributed disease being markedly more prevalent in women aged
Subject: Squamous intraepithelial lesions of the cervix
Prevalence
HPV human papillomavirus
Genotype
PAPILLOMAVIRUS VACCINATION PROGRAM
INTRAEPITHELIAL NEOPLASIA
GENOTYPE DISTRIBUTION
PARTICLE VACCINE
HERD-IMMUNITY
DOUBLE-BLIND
FOLLOW-UP
CANCER
PREVALENCE
INFECTION
3122 Cancers
3123 Gynaecology and paediatrics
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