Age-specific HPV type distribution in high-grade cervical disease in screened and unvaccinated women

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Aro , K , Nieminen , P , Louvanto , K , Jakobsson , M , Virtanen , S , Lehtinen , M , Dillner , J & Kalliala , I 2019 , ' Age-specific HPV type distribution in high-grade cervical disease in screened and unvaccinated women ' , Gynecologic Oncology , vol. 154 , no. 2 , pp. 354-359 . https://doi.org/10.1016/j.ygyno.2019.05.024

Title: Age-specific HPV type distribution in high-grade cervical disease in screened and unvaccinated women
Author: Aro, Karoliina; Nieminen, Pekka; Louvanto, Karolina; Jakobsson, Maija; Virtanen, Seppo; Lehtinen, Matti; Dillner, Joakim; Kalliala, Ilkka
Contributor organization: Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
University of Helsinki
University Management
Clinicum
Staff Services
Date: 2019-08
Language: eng
Number of pages: 6
Belongs to series: Gynecologic Oncology
ISSN: 0090-8258
DOI: https://doi.org/10.1016/j.ygyno.2019.05.024
URI: http://hdl.handle.net/10138/306343
Abstract: Background and aim. Age-specific type-distribution of high-risk human papillomavirus (hrHPV) in cervical precancerous lesions is subject to change in the HPV vaccination era. Knowing the pre-vaccination type distribution helps to anticipate changes induced by mass vaccination and optimize screening. Methods. We recruited 1279 women referred to colposcopy for abnormal cytology into a population-based study on HPV type distribution in diagnostic cervical samples (ISRCTN10933736). The HPV genotyping findings were grouped as: HPV16/18+, other hrHPV+ (HPV31/33/35/39/45/51/52/56/58/59/66/68), non-vaccine targeted hrHPV+ (HPV35/39/51/56/59/66/68), low-risk HPV, and HPV negative. We estimated the HPV group-specific prevalence rates according to diagnostic histopathological findings in the age groups of = 45 (n = 326). Results. Altogether 503 cases with high grade squamous intraepithelial lesion or worse (HSIL+) were diagnosed. More than half, 285 (56.7%) of HSIL+ cases were associated with HPV16/18: 64.3% (101/157) in women = 45 years of age (RR 0.55, 95% CI 039-0.75). Conversely, other hrHPV's were associated with 191 (38.0%) of HSIL+: 31.9% (50/157) in women = 45 (RR 1.71, 95% CI 126-2.33). The proportion of non-vaccine targeted hrHPV and HPV negative HSIL+ increased with advancing age. Conclusions. Pre-vaccination HPV type distribution in HSIL+ was distinctly polarised by age with HPV16/18 attributed disease being markedly more prevalent in women aged
Subject: Squamous intraepithelial lesions of the cervix
Prevalence
HPV human papillomavirus
Genotype
PAPILLOMAVIRUS VACCINATION PROGRAM
INTRAEPITHELIAL NEOPLASIA
GENOTYPE DISTRIBUTION
PARTICLE VACCINE
HERD-IMMUNITY
DOUBLE-BLIND
FOLLOW-UP
CANCER
PREVALENCE
INFECTION
3122 Cancers
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion


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