Joint Associations of Maternal Gestational Diabetes and Hypertensive Disorders of Pregnancy With Overweight in Offspring

Show full item record



Permalink

http://hdl.handle.net/10138/306680

Citation

Gu , Y , Lu , J , Li , W , Liu , H , Wang , L , Leng , J , Li , W , Zhang , S , Wang , S , Tuomilehto , J , Yu , Z , Yang , X , Baccarelli , A A , Hou , L & Hu , G 2019 , ' Joint Associations of Maternal Gestational Diabetes and Hypertensive Disorders of Pregnancy With Overweight in Offspring ' , Frontiers in Endocrinology , vol. 10 , 645 . https://doi.org/10.3389/fendo.2019.00645

Title: Joint Associations of Maternal Gestational Diabetes and Hypertensive Disorders of Pregnancy With Overweight in Offspring
Author: Gu, Yuying; Lu, Jun; Li, Weiqin; Liu, Huikun; Wang, Leishen; Leng, Junhong; Li, Wei; Zhang, Shuang; Wang, Shuting; Tuomilehto, Jaakko; Yu, Zhijie; Yang, Xilin; Baccarelli, Andrea A.; Hou, Lifang; Hu, Gang
Contributor: University of Helsinki, Clinicum
Date: 2019-09-20
Language: eng
Number of pages: 7
Belongs to series: Frontiers in Endocrinology
ISSN: 1664-2392
URI: http://hdl.handle.net/10138/306680
Abstract: Objectives: Either maternal gestational diabetes mellitus (GDM) or hypertensive disorder of pregnancy (HDP) is associated with an increased risk of obesity in the offspring. However, their joint associations with obesity in offspring remain unclear. We investigated the joint associations of maternal GDM and HDP with childhood overweight in offspring.Methods: We performed a large study in 1967 mother-child pairs. Maternal GDM was diagnosed according to the 1999 World Health Organization (WHO) criteria. HDP was defined as self-reported doctor-diagnosed hypertension or treatment of hypertension (including gestational hypertension, preeclampsia, sever preeclampsia or eclampsia) after 20 weeks of gestation on the questionnaire. Body mass index (BMI) for age Z-score and childhood overweight were evaluated according to WHO growth reference. We used the general linear models to compare children's Z score for BMI and logistic regression models to estimate odds ratios of childhood overweight according to maternal different status of GDM and HDP.Results: Offspring of mothers with both GDM and HDP had a higher BMI for age Z-score (0.63 vs. 0.03, P <0.001) than children born to normotensive and normoglycemic pregnancy. After adjustment for maternal and children's major confounding factors, joint GDM and HDP were associated with increased odds ratios of offspring's overweight compared with normotensive and normoglycemic pregnancy (2.97, 95% confidence intervals [CIs] 1.65–5.34) and GDM alone (2.06, 95% CIs 1.20–3.54), respectively. After additional adjustment for maternal pre-pregnancy BMI and gestational weight gain, joint maternal GDM, and HDP was still associated with an increased risk of offspring's overweight compared with the maternal normotensive, and normoglycemic group but became to have a borderline increased risk compared with the maternal GDM alone group.Conclusions: Maternal GDM alone or joint GDM and HDP were associated with increased ratios of offspring's overweight.
Subject: 3121 General medicine, internal medicine and other clinical medicine
gestational diabetes mellitus
hypertensive disorders of pregnancy
overweight
obesity
childhood
INSULIN-RESISTANCE
CLINICAL CHARACTERISTICS
CARDIOMETABOLIC RISK
CARDIOVASCULAR RISK
METABOLIC SYNDROME
CHILDHOOD OBESITY
YOUNG ADULTHOOD
WOMEN
PREECLAMPSIA
PREVALENCE
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
fendo_10_00645.pdf 214.0Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record