Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension

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Puustinen , T , Tervonen , J , Avellan , C , Jyrkkänen , H-K , Paterno , J J , Hartikainen , P , Vanhanen , U , Leinonen , V , Lehto , S M , Elomaa , A-P & Huttunen , T J 2019 , ' Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension ' , Clinical Neurology and Neurosurgery , vol. 186 , 105527 . https://doi.org/10.1016/j.clineuro.2019.105527

Title: Psychiatric disorders are a common prognostic marker for worse outcome in patients with idiopathic intracranial hypertension
Author: Puustinen, Tero; Tervonen, Joona; Avellan, Cecilia; Jyrkkänen, Henna-Kaisa; Paterno, Jussi J.; Hartikainen, Päivi; Vanhanen, Ulla; Leinonen, Ville; Lehto, Soili M.; Elomaa, Antti-Pekka; Huttunen, Terhi J.
Contributor: University of Helsinki, Department of Psychology and Logopedics
Date: 2019-11
Language: eng
Number of pages: 6
Belongs to series: Clinical Neurology and Neurosurgery
ISSN: 0303-8467
URI: http://hdl.handle.net/10138/307823
Abstract: Objective Idiopathic intracranial hypertension (IIH) is aetiologically unknown disorder that associates with endocrinological disturbances, including dysfunction of hypothalamic-pituitary-adrenal-axis. Neuroendocrinological dysfunctions have also been characterized in psychiatric disorders, and therefore we investigated the presence of psychiatric disorders of patients with IIH in a well-defined cohort. Patients and Methods A total of 51 patients with IIH were included. Patient demographics, symptoms, imaging data, ophthalmological and clinical findings were collected. Results At the time of diagnosis the mean age was 32.5years (SD 10.7), the body mass index was 37.1 kg/m2 (SD 7.4), and the opening pressure 29.1 mmHg (SD 6.2). A total of 88.2% of patients were female and 45.1% were diagnosed with a psychiatric co-morbidity prior to IIH diagnosis. The mean follow-up time was 4.4 years (SD 5.4). The overall treatment outcome was significantly poorer on a group of patients with psychiatric diagnosis when compared to individuals without such history (p = 0.001), but there were no differences in the resolution of papilledema (p = 0.405). Patients with IIH and psychiatric disorders had more often empty sella on their imaging at diagnosis when compared to patients without psychiatric co-morbidity (p = 0.044). Conclusion Psychiatric disorders are highly prevalent in patients with IIH and associate with worse subjective outcomes. These findings advocate for monitoring the mental health of patients with IIH and warrant further multidisciplinary research to understand the potentially underlying psychosocial and neuroendocrinological mechanisms.
Subject: 3124 Neurology and psychiatry
3126 Surgery, anesthesiology, intensive care, radiology
Idiopathic intracranial hypertension (IIH)
psychiatric disorders
major depressive disorder (MDD)
hypothalamic-pituitary-adrenal-axis (HPA-axis)
intracranial pressure (ICP)
Hypothalamic-pituitary-adrenal-axis (HPA-axis)
DEPRESSION
PSEUDOTUMOR CEREBRI
PREVALENCE
Intracranial pressure (ICP)
Major depressive disorder (MDD)
BARIATRIC SURGERY
Psychiatric disorders
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