Lyophilic matrix method for dissolution and release studies of nanoscale particles

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http://hdl.handle.net/10138/307963

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Pessi , J , Svanbäck , S , Lassila , I , Haeggstrom , E & Yliruusi , J 2017 , ' Lyophilic matrix method for dissolution and release studies of nanoscale particles ' , Journal of Pharmaceutical and Biomedical Analysis , vol. 145 , pp. 549-554 . https://doi.org/10.1016/j.jpba.2017.07.017

Title: Lyophilic matrix method for dissolution and release studies of nanoscale particles
Author: Pessi, Jenni; Svanbäck, Sami; Lassila, Ilkka; Haeggstrom, Edward; Yliruusi, Jouko
Contributor organization: Faculty of Pharmacy
Division of Pharmaceutical Chemistry and Technology
Department of Physics
Materials Physics
Jouko Yliruusi / Principal Investigator
Date: 2017-10-25
Language: eng
Number of pages: 6
Belongs to series: Journal of Pharmaceutical and Biomedical Analysis
ISSN: 0731-7085
DOI: https://doi.org/10.1016/j.jpba.2017.07.017
URI: http://hdl.handle.net/10138/307963
Abstract: We introduce a system with a lyophilic matrix to aid dissolution studies of powders and particulate systems. This lyophilic matrix method (LM method) is based on the ability to discriminate between non-dissolved particles and the dissolved species. In the LM method the test substance is embedded in a thin lyophilic core-shell matrix. This permits rapid contact with the dissolution medium while minimizing dispersion of non-dissolved particles without presenting a substantial diffusion barrier. The method produces realistic dissolution and release results for particulate systems, especially those featuring nanoscale particles. By minimizing method-induced effects on the dissolution profile of nanopowders, the LM method overcomes shortcomings associated with current dissolution tests. (C) 2017 Elsevier B.V. All rights reserved.
Subject: Dissolution
Dissolution rate
Drug release
Particulate systems
Nanoparticles
Lyophilic matrix method
DRUG-RELEASE
DOSAGE FORMS
NANOPARTICLES
APPARATUS
SYSTEMS
VARIABILITY
KINETICS
CLASSIFICATION
MICRODIALYSIS
TABLETS
317 Pharmacy
116 Chemical sciences
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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