Lyophilic matrix method for dissolution and release studies of nanoscale particles

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http://hdl.handle.net/10138/307963

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Pessi , J , Svanbäck , S , Lassila , I , Haeggstrom , E & Yliruusi , J 2017 , ' Lyophilic matrix method for dissolution and release studies of nanoscale particles ' , Journal of Pharmaceutical and Biomedical Analysis , vol. 145 , pp. 549-554 . https://doi.org/10.1016/j.jpba.2017.07.017

Title: Lyophilic matrix method for dissolution and release studies of nanoscale particles
Author: Pessi, Jenni; Svanbäck, Sami; Lassila, Ilkka; Haeggstrom, Edward; Yliruusi, Jouko
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Department of Physics
University of Helsinki, Department of Physics
University of Helsinki, Faculty of Pharmacy
Date: 2017-10-25
Language: eng
Number of pages: 6
Belongs to series: Journal of Pharmaceutical and Biomedical Analysis
ISSN: 0731-7085
URI: http://hdl.handle.net/10138/307963
Abstract: We introduce a system with a lyophilic matrix to aid dissolution studies of powders and particulate systems. This lyophilic matrix method (LM method) is based on the ability to discriminate between non-dissolved particles and the dissolved species. In the LM method the test substance is embedded in a thin lyophilic core-shell matrix. This permits rapid contact with the dissolution medium while minimizing dispersion of non-dissolved particles without presenting a substantial diffusion barrier. The method produces realistic dissolution and release results for particulate systems, especially those featuring nanoscale particles. By minimizing method-induced effects on the dissolution profile of nanopowders, the LM method overcomes shortcomings associated with current dissolution tests. (C) 2017 Elsevier B.V. All rights reserved.
Subject: Dissolution
Dissolution rate
Drug release
Particulate systems
Nanoparticles
Lyophilic matrix method
DRUG-RELEASE
DOSAGE FORMS
NANOPARTICLES
APPARATUS
SYSTEMS
VARIABILITY
KINETICS
CLASSIFICATION
MICRODIALYSIS
TABLETS
317 Pharmacy
116 Chemical sciences
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