Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos

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http://hdl.handle.net/10138/307994

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Abu Saleh , D , Niskanen , J , Xue , Y , Golberg , D , Winnik , F M & Sosnik , A 2017 , ' Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos ' , Materials today chemistry , vol. 6 , pp. 45-50 . https://doi.org/10.1016/j.mtchem.2017.09.003

Title: Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos
Author: Abu Saleh, Doaa; Niskanen, Jukka; Xue, Yanming; Golberg, Dmitri; Winnik, Francoise M.; Sosnik, Alejandro
Contributor: University of Helsinki, Department
University of Helsinki, Polymers
Date: 2017-12
Language: eng
Number of pages: 6
Belongs to series: Materials today chemistry
ISSN: 2468-5194
URI: http://hdl.handle.net/10138/307994
Abstract: We report an organic-inorganic hybrid core-shell nanomaterial obtained by conjugation of an amphiphilic monomethoxy-poly(ethylene glycol)-b-poly(epsilon-caprolactone) diblock copolymer to hydroxylated boron nitride nanotubes (BNNTs). The extent of copolymer grafting reached 64% w/w, an exceptionally high value. The hybrid materials exhibit excellent physical stability in water and an outstanding loading capacity (31.3% w/w) for curcumin, a hydrophobic drug. Moreover, they present good compatibility with the Caco2 cell line, a model of intestinal epithelium. Our findings demonstrate the potential of multifunctional hybrid BNNTs to serve as a platform for complex amphiphilic nanoparticle architectures with improved features. (c) 2017 Elsevier Ltd. All rights reserved.
Subject: Core-shell amphiphilic hybrid nanomaterials
Boron nitride nanotubes
Polymeric micelles
Drug encapsulation
Curcumin
CARBON NANOTUBES
DRUG-DELIVERY
CELL-LINE
CURCUMIN
FUNCTIONALIZATION
STABILITY
CYTOCOMPATIBILITY
INTERNALIZATION
NANOPARTICLES
CONDUCTIVITY
116 Chemical sciences
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