ALK and EGFR expression by immunohistochemistry are associated with Merkel cell polyomavirus status in Merkel cell carcinoma

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http://hdl.handle.net/10138/308748

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Veija , T , Kero , M , Koljonen , V & Böhling , T 2019 , ' ALK and EGFR expression by immunohistochemistry are associated with Merkel cell polyomavirus status in Merkel cell carcinoma ' , Histopathology , vol. 74 , no. 6 , pp. 829-835 . https://doi.org/10.1111/his.13815

Title: ALK and EGFR expression by immunohistochemistry are associated with Merkel cell polyomavirus status in Merkel cell carcinoma
Author: Veija, Tuukka; Kero, Mia; Koljonen, Virve; Böhling, Tom
Contributor: University of Helsinki, Department of Pathology
University of Helsinki, HUSLAB
University of Helsinki, Plastiikkakirurgian yksikkö
University of Helsinki, Department of Pathology
Date: 2019-05
Language: eng
Number of pages: 7
Belongs to series: Histopathology
ISSN: 0309-0167
URI: http://hdl.handle.net/10138/308748
Abstract: Aims Merkel cell carcinoma, a rare cutaneous neuroendocrine tumour of the skin, can be categorised into two groups according to Merkel cell polyomavirus (MCV) presence. MCV-negative tumours are more aggressive and frequently associated with gene mutations. Some of the genes are potential therapeutic targets. We have previously reported EGFR mutations in six of 27 MCC tumours and overexpression of ALK and EZH2 at mRNA level in MCC tumours. In this study, we sought to determine expression of ALK, EGFR and EZH2 in MCC samples and assess their correlation to MCV status and clinical parameters. Methods and results Tissue microarrays were utilised and stained with primary antibodies. Staining data were statistically compared to patient sex, tumour location and development of metastasis and MCC-specific death; 112 tumours and their corresponding patient data were included. We found strong expression of ALK in 51% and strong expression of EZH2 in 76% of the tumours. There was evident correlation of ALK expression with MCV-positivity. Expression of EGFR was infrequent, presenting only in seven MCV-negative tumours. None of the proteins associated with development of metastasis or MCC specific death. Conclusions ALK and EZH2 expression are frequent in MCC and ALK expression correlates to MCV positivity. EGFR positive tumours might respond to EGFR inhibiting treatment.
Subject: 3111 Biomedicine
Merkel cell carcinoma
Merkel cell polyomavirus
immunohistochemistry
protein expression
sensitivity
antibody
infection
mutations
EZH2
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