Drug nanocrystals - versatile option for formulation of poorly soluble materials

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http://hdl.handle.net/10138/309042

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Peltonen , L & Hirvonen , J 2018 , ' Drug nanocrystals - versatile option for formulation of poorly soluble materials ' , International Journal of Pharmaceutics , vol. 537 , no. 1-2 , pp. 73-83 . https://doi.org/10.1016/j.ijpharm.2017.12.005

Title: Drug nanocrystals - versatile option for formulation of poorly soluble materials
Author: Peltonen, Leena; Hirvonen, Jouni
Contributor organization: Faculty of Pharmacy
Division of Pharmaceutical Chemistry and Technology
Preclinical Drug Formulation and Analysis group
Drug Research Program
Jouni Hirvonen / Principal Investigator
Date: 2018-02-15
Language: eng
Number of pages: 11
Belongs to series: International Journal of Pharmaceutics
ISSN: 0378-5173
DOI: https://doi.org/10.1016/j.ijpharm.2017.12.005
URI: http://hdl.handle.net/10138/309042
Abstract: Poor solubility of drug compounds is a great issue in drug industry today and decreasing particle size is one efficient and simple way to overcome this challenge. Drug nanocrystals are solid nanosized drug particles, which are covered by a stabilizer layer. In nanoscale many physical properties, like compound solubility, are different from the solubility of bulk material, and due to this drug nanocrystals can reach supersaturation as compared to thermodynamic solubility. The most important effect of the smaller particle size is that dissolution rate is highly enhanced mainly due to the increased surface area. In this review the most important properties of nanocrystalline drug compounds are presented, with multiple examples of the development and characterization of nanocrystalline drug formulations.
Subject: Drug nanocrystals
Poor solubility
Formulation
CRITICAL QUALITY ATTRIBUTES
CRITICAL PROCESS PARAMETERS
IN-VIVO EVALUATION
VITAMIN-E TPGS
ORAL BIOAVAILABILITY
PHYSICOCHEMICAL CHARACTERIZATION
PHARMACEUTICAL COCRYSTALS
DISSOLUTION ENHANCEMENT
PACLITAXEL NANOCRYSTALS
DELIVERY-SYSTEMS
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion


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